Schwager K
Klinik und Poliklinik für Hals-, Nasen- und Ohrenkranke der Universität Würzburg.
Laryngorhinootologie. 2000 Dec;79(12):762-6. doi: 10.1055/s-2000-9137.
Titanium as a biomaterial in ossicular replacement has widely spread within the last couple of years.
23 prostheses (12 PORPs, partial ossicular replacement prostheses and 11 TORPs total ossicular replacement prostheses) removed during revision surgery were studied using scanning electron microscopy. The average implantation time was 8 (range 3-15) months. The specimens were investigated regarding tissue growth, epithelialization, inflammation and cellular signs of rejection.
Only few prostheses were totally covered by connective tissue or epithelium due to technical problems in removing the implant and the covering tissue as one specimen. But this offered the possibility to study the interface at the edges where the tissue was torn off. The connective tissue looked unremarkable. Polygonal squamous epithelium was detected on several implants. Respiratory epithelium with ciliated cells and mucus producing goblet cells was seen in two specimens. In cases of cholesteatoma or protrusion the explanted prostheses showed typical rosette-like formation of hornifying squamous epithelium. According to underlying disease a lymphocytic infiltration could be seen. There were no cellular signs of incompatibility noticed neither macrophages nor foreign body giant cells.
From these investigations titanium seems to be a favorable biomaterial for ossicular replacement with good acceptance also in an implantation site showing chronic inflammation.
钛作为一种用于听骨置换的生物材料，在过去几年中已广泛应用。
对翻修手术中取出的23个假体（12个部分听骨置换假体PORP和11个全听骨置换假体TORP）进行扫描电子显微镜研究。平均植入时间为8个月（范围3 - 15个月）。对标本进行组织生长、上皮化、炎症及排斥反应细胞迹象方面的研究。
由于将植入物和覆盖组织作为一个标本取出时存在技术问题，仅有少数假体被结缔组织或上皮完全覆盖。但这提供了研究组织被撕下边缘处界面的可能性。结缔组织外观无异常。在多个植入物上检测到多边形鳞状上皮。在两个标本中可见带有纤毛细胞和产生黏液杯状细胞的呼吸道上皮。在胆脂瘤或突出病例中，取出的假体显示出典型的角质化鳞状上皮玫瑰花结样形成。根据潜在疾病情况可见淋巴细胞浸润。未发现不相容的细胞迹象，既没有巨噬细胞也没有异物巨细胞。
从这些研究来看，钛似乎是一种用于听骨置换的良好生物材料，在显示慢性炎症的植入部位也具有良好的耐受性。
