Emdogain: evidence of efficacy.

This article addresses the use of enamel matrix proteins (Emdogain) to enhance regeneration of the periodontium. Information regarding the role of Emdogain to induce cementogenesis and histologic evidence in animals and humans that it can initiate regeneration of diseased sites are discussed. Several clinical trials have indicated that Emdogain plus modified Widman flap surgery provide a better result than the surgery alone. Several other investigations have indicated that flap surgery plus Emdogain or a bioabsorbable membrane achieve similar results. However, this latter finding needs further validation. Clinical examples of successful therapy with Emdogain are presented.