Kopiński P
Katedra Patofizjologii Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
Przegl Lek. 2000;57(9):493-8.
Actual characteristics of alveolar lymphocytes was presented, including author's own experience, i.e. bronchoalveolar lavage (BAL) lymphocyte typing in over 450 patients with interstitial lung diseases (ILD) and bronchial asthma. In healthy individuals as well as in the patients, alveolar lymphocyte population is dominated by T cell subset. Alveolar T lymphocytes present primed memory cell phenotype and usually do not proliferate; in normal conditions apoptosis occurs very seldom. T cytotoxic cell phenotype is characteristic for CD8 subset. Percent of B and NK cells found in BAL is very low--B cells are localized in interstitial space around the pulmonary alveoli, while NK cells do not seem to play the important role in the local pulmonary defense. CD4/CD8 ratio evaluation in BAL material is an auxiliary tool in ILD diagnostics; it reflects local imbalance between T helper primed memory cells and primed T cytotoxic cells.
本文介绍了肺泡淋巴细胞的实际特征，包括作者自身的经验，即在450多名间质性肺病（ILD）和支气管哮喘患者中进行支气管肺泡灌洗（BAL）淋巴细胞分型。在健康个体和患者中，肺泡淋巴细胞群体均以T细胞亚群为主。肺泡T淋巴细胞呈现致敏记忆细胞表型，通常不增殖；在正常情况下，凋亡很少发生。T细胞毒性细胞表型是CD8亚群的特征。在BAL中发现的B细胞和NK细胞百分比非常低——B细胞位于肺泡周围的间质空间，而NK细胞似乎在局部肺部防御中不发挥重要作用。对BAL材料进行CD4/CD8比值评估是ILD诊断的辅助工具；它反映了T辅助致敏记忆细胞和致敏T细胞毒性细胞之间的局部失衡。
