Petrek M, Kolek V
Oddĕlení imunologie FN Olomouc.
Cas Lek Cesk. 1993 Jun 14;132(12):365-8.
In the bronchoalveolar lavage of 17 patients with pulmonary sarcoidosis and in the lavage of 18 patients with other diseases of the pulmonary interstitium the authors assessed by means of monoclonal antibodies, T-lymphocyte subpopulations. In the lavage from sarcoidosis helper-inducer lymphocytes (CD4+) dominated markedly, while in other interstitial pulmonary diseases a predominance of suppressor-cytotoxic lymphocytes (CD8+) was found. The different ratio of CD4+ and CD8+ lymphocytes was manifested particularly markedly when for evaluation the CD4/CD8 ratio was used: in sarcoidosis it was 7.2 +/- 3.5, while in other interstitial lung diseases only 0.9 +/- 0.6. The presented results indicate possible practical use of assessment of lymphocyte subpopulations in bronchoalveolar lavage for the differential diagnosis of interstitial lung diseases.
作者通过单克隆抗体对17例肺结节病患者的支气管肺泡灌洗样本以及18例患有其他肺间质疾病患者的灌洗样本进行了T淋巴细胞亚群评估。在结节病患者的灌洗样本中，辅助诱导淋巴细胞（CD4+）显著占主导，而在其他间质性肺疾病患者的灌洗样本中，则发现抑制性细胞毒性淋巴细胞（CD8+）占优势。当使用CD4/CD8比值进行评估时，CD4+和CD8+淋巴细胞的不同比例表现得尤为明显：在结节病中该比值为7.2±3.5，而在其他间质性肺疾病中仅为0.9±0.6。所呈现的结果表明，支气管肺泡灌洗中淋巴细胞亚群的评估在间质性肺疾病的鉴别诊断中可能具有实际应用价值。
