Wilimowska J
Klinika Toksykologii KMPiChS, Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
Przegl Lek. 2000;57(10):568-71.
The biological material of 28 abusers of compounds from the group of opium alkaloids were toxicologically analysed. To preliminary estimation of psychoactive substances ingestion the immunoassay methods (EMIT or FPIA) were used. The received results of total estimation compounds from opium alkaloids and their metabolites were compared to the ones obtained from high-performance liquid chromatography identification method with using Remedi HS. In the evaluated materials of all patients morphine, codeine, N-desmethylcodeine were identified. The presence of 6-mono-acethylmorphine was found in the urine of only 4 patients, which indicates the instability and a little amount of heroine in "kompot" of domestic production. The identification method can be used for simultaneous estimation of other substances of abuse from the groups of amphetamines and phenothiazines.
对28名鸦片生物碱类化合物滥用者的生物材料进行了毒理学分析。为初步评估精神活性物质的摄入情况，采用了免疫分析方法（酶倍增免疫测定技术或荧光偏振免疫分析）。将鸦片生物碱及其代谢物的总评估结果与使用Remedi HS的高效液相色谱鉴定法所获得的结果进行了比较。在所有患者的评估材料中均鉴定出吗啡、可待因、N-去甲基可待因。仅在4名患者的尿液中发现了6-单乙酰吗啡，这表明国产“康波特”中存在海洛因的不稳定性和少量情况。该鉴定方法可用于同时评估苯丙胺类和吩噻嗪类其他滥用物质。
