Klimaszyk D
Oddział Chorób Zawodowych i Toksykologii im. dr Wandy Błeńskiej, Wielkopolskiego Centrum Medycyny Pracy w Poznaniu.
Przegl Lek. 2000;57(10):600-5.
Data based on experience of Regional Toxicological Centre in Poznań shown that most of patients self-poisoned with calcium channel blockers were cases of verapamil overdose (41 among 50 patients treated during years 1994-1999). Verapamil's greatest toxic effect is on the conduction system, with depression of the sinus node and of conduction through the atrioventricular node, but it also causes severe myocardial depression. Sings of verapamil toxicity are: sinus bradycardia, sinus arrest, narrow complex junctional bradycadia, varying degrees of AV block, acute congestive failure and cardiogenic shock, hypotonia. In this paper 4 cases with ECG disturbances in the course of verapamil intoxication are presented.
基于波兹南地区毒理学中心的经验数据显示，大多数服用钙通道阻滞剂进行自我中毒的患者是维拉帕米过量中毒的病例（在1994年至1999年期间接受治疗的50名患者中有41例）。维拉帕米最大的毒性作用在于传导系统，可抑制窦房结以及通过房室结的传导，但它也会导致严重的心肌抑制。维拉帕米中毒的症状有：窦性心动过缓、窦性停搏、窄QRS波交界性心动过缓、不同程度的房室传导阻滞、急性充血性心力衰竭和心源性休克、肌张力减退。本文介绍了4例在维拉帕米中毒过程中出现心电图异常的病例。
