Grage-Griebenow E, Flad H D, Ernst M
Experimental Pneumology, Ruhr-University Bochum, Germany.
J Leukoc Biol. 2001 Jan;69(1):11-20.
In recent years the number of reports describing phenotypically and functionally distinct subsets of human blood leukocytes, and in particular of subtypes of antigen-presenting cells has continuously increased. A great diversity was described not only for dendritic cells (DC), but also for human blood monocytes (Mo) and macrophages (Mac). Similar to DC, the different types of Mo subsets could be defined by distinct phenotypes and immunoregulatory functions. The characterization of blood Mo subpopulations revealed that some of them exhibit common features with myeloid or lymphoid DC and tissue Mac, but also demonstrate the existence of novel unique cell populations. The generation of lymphoid and myeloid DC and their heterogeneity has been the subject of recent reviews. Here we focus on Mo from human peripheral blood and summarize the data (including our own) dealing with their phenotypic and functional, in particular immunoregulatory properties.
近年来，描述人类血液白细胞表型和功能不同亚群，特别是抗原呈递细胞亚群的报告数量持续增加。不仅树突状细胞（DC），人类血液单核细胞（Mo）和巨噬细胞（Mac）也表现出高度多样性。与DC相似，不同类型的Mo亚群可通过不同的表型和免疫调节功能来定义。血液Mo亚群的特征表明，其中一些与髓样或淋巴样DC以及组织Mac具有共同特征，但也证明了新型独特细胞群体的存在。淋巴样和髓样DC的产生及其异质性已成为近期综述的主题。在此，我们聚焦于人类外周血中的Mo，并总结（包括我们自己的）有关其表型和功能，特别是免疫调节特性的数据。
