1H, 13C and 15N resonance assignments of the SNT PTB domain in complex with FGFR1 peptide.

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作者信息

Dhalluin C, Yan K S, Plotnikova O, Zeng L, Goldfarb M P, Zhou M M

出版信息

J Biomol NMR. 2000 Dec;18(4):371-2. doi: 10.1023/a:1026725919008.

DOI:10.1023/a:1026725919008

PMID:11200536

Abstract

摘要

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FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.FRS2蛋白通过与成纤维细胞生长因子和神经生长因子受体上的多种靶点结合来募集细胞内信号通路。

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Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.Shp2 酪氨酸磷酸酶与 FRS2 的结合对于成纤维细胞生长因子诱导的 PC12 细胞分化至关重要。

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CNTF, FGF, and NGF collaborate to drive the terminal differentiation of MAH cells into postmitotic neurons.睫状神经营养因子、成纤维细胞生长因子和神经生长因子协同作用，促使中脑前体细胞终末分化为有丝分裂后的神经元。

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Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: a sequence of events in sympathetic development.碱性成纤维细胞生长因子诱导嗜铬细胞的神经元分化、细胞分裂和对神经生长因子的依赖性：交感神经发育中的一系列事件。

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