[在俄罗斯发现的人类免疫缺陷病毒1型gag和env基因的核苷酸序列：新重组变体的检测]
[Nucleotide sequence of gag and env genes of human immunodeficiency virus type 1, found in Russia: detection of new recombinant variants].
作者信息
Bobkov A F, Kazennova E V, Selimova L M, Khanina T A, Bobkova M R, Ladnaia N N, Kravchenko A V, Pokrovskiĭ V V, Weber J N
出版信息
Vopr Virusol. 2000 Nov-Dec;45(6):17-20.
Phylogenetic analysis of nucleotide sequences of gag and env genes of type 1 human immunodeficiency virus (HIV-1) variants isolated from individuals infected through sexual intercourse or nosocomially (by injections with nonsterile syringes) showed that 5 of 27 (18.5%) isolated strains were recombinants. Two viruses found in the Russian Far East had gagAenvE genotype, three other recombinants had envG genotype; gag gene of one isolate belonged to subtype A and gag genes of two others belonged to subtype D. Detection of new recombinant variants in addition to the A/B recombinant described previously shows that these viruses can contribute to the HIV-1 genetic variability in Russia.
对从通过性行为感染或医院感染（使用非无菌注射器注射）的个体中分离出的1型人类免疫缺陷病毒（HIV-1）变体的gag和env基因核苷酸序列进行系统发育分析表明，27株分离菌株中有5株（18.5%）为重组体。在俄罗斯远东地区发现的两种病毒具有gagAenvE基因型，其他三种重组体具有envG基因型；一株分离株的gag基因属于A亚型，另外两株的gag基因属于D亚型。除了先前描述的A/B重组体外，新重组变体的检测表明这些病毒可能导致俄罗斯HIV-1的遗传变异性。
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