[新西伯利亚患者丙型肝炎及其各种基因型的标志物]

[Markers of hepatitis C and its various genotypes in patients from Novosibirsk].

作者信息

Shustov A V, Mishin V P, Maksiutov A Z, Kiseleva N N, Sakharova E G, Tolokonskaia N P, Robertson B J, Netesov S V

出版信息

Vopr Virusol. 2000 Nov-Dec;45(6):22-7.

PMID:11200641

Abstract

Study of the prevalence of hepatitis C virus (HCV) markers in 153 patients of Municipal Infectious Diseases Clinical Hospital No. 1 in Novosibirsk revealed anti-HCV in 88.2% patients and viral RNA in 69.3% samples. For 93 Siberian HCV isolates 5'-UTR regions were amplified and sequenced. Comparison of these nucleotide sequences with databank showed that 63.4% HCV isolates belonged to subtype 1b, 7.5% to genotype 2, and 18.3% to genotype 3. In the rest HCV isolates the 5'-UTR sequences contained heretofore undescribed nucleotide substitutions, insertions, or deletions.

摘要

对新西伯利亚市第一市立传染病临床医院153例患者丙型肝炎病毒（HCV）标志物流行情况的研究发现，88.2%的患者存在抗-HCV，69.3%的样本存在病毒RNA。对93株西伯利亚HCV分离株的5'-UTR区域进行了扩增和测序。将这些核苷酸序列与数据库进行比较，结果显示63.4%的HCV分离株属于1b亚型，7.5%属于2基因型，18.3%属于3基因型。其余HCV分离株的5'-UTR序列含有迄今未描述的核苷酸替换、插入或缺失。