Kolarzyk E, Pach J
Zakładu Higieny i Ekologii CMUJ.
Pneumonol Alergol Pol. 2000;68(7-8):303-11.
The aim of this study was to evaluate the respiratory efficiency in alcohol and opiate abusers. There were 220 persons under examination: 144 alcohol abusers (group I), 36 opiate abusers (group II) and 40 healthy persons (control group). Both groups of dependent persons were treated in the Detoxication Unit of the Department of Clinical Toxicology CMUJ. During hospitalization the functional state of respiratory system was monitored. Ventilation efficiency was determined on the basis of the results from a "flow-volume" loop, spirometry and the measurements of the respiratory tract resistance in a computerised system Lungtest-MES company (Poland). In the examination performed directly after admission to the Clinic the normal respiratory efficiency was noted in 36.1% in ethanol abusers and 54.9% in opiate abusers. 63.9% of alcohol abusers (group I) and 45.1% of opiate abusers (group II) suffered from the bronchial obturation. In the examination performed after hospitalisation and 9 days of total abstinence in 33.3% of the alcohol dependent patients and in 38.5% of the opiate dependent patients respiratory obturation was observed. The values of respiratory tract resistance in both groups of dependent patients in examination on admission and after treatment were increased compared to controls. The changes of ventilatory parameters can be explained mainly by withdrawal syndrom revealing that it is connected with initial (9 days lasting) period of controlled and total abstinence.
本研究的目的是评估酒精和阿片类药物滥用者的呼吸效率。共有220人接受检查：144名酒精滥用者（第一组），36名阿片类药物滥用者（第二组）和40名健康人（对照组）。两组依赖者均在CMUJ临床毒理学系戒毒科接受治疗。住院期间监测呼吸系统的功能状态。通气效率是根据“流量-容积”环、肺活量测定结果以及在波兰Lungtest-MES公司的计算机系统中测量呼吸道阻力来确定的。在入院后立即进行的检查中，发现酒精滥用者中36.1%呼吸效率正常，阿片类药物滥用者中54.9%呼吸效率正常。63.9%的酒精滥用者（第一组）和45.1%的阿片类药物滥用者（第二组）患有支气管阻塞。在住院和完全戒酒9天后进行的检查中，33.3%的酒精依赖患者和38.5%的阿片类药物依赖患者出现呼吸阻塞。与对照组相比，两组依赖患者入院时和治疗后的呼吸道阻力值均升高。通气参数的变化主要可以用戒断综合征来解释，这表明它与持续9天的控制和完全戒酒的初始阶段有关。
