Kolarzyk E, Pach J
Zakładu Higieny i Ekologii CMUJ.
Pneumonol Alergol Pol. 2000;68(7-8):312-8.
Opioid drugs and alcohol, both central nervous system depressants, may also have a depressive action on the brain stem centre responsible for breathing control. Disorders of breathing regulation are reflected in respiratory efficiency. The aim of this study was to evaluate the regulation of breathing by measuring the respiratory pattern and occlusion pressure of abusers of opiates and alcohol. There were 180 persons under examination: 84 alcohol abusers (group I), 36 opiates abusers (group II) and 40 healthy persons (control group). Both groups of dependent persons were treated in the Detoxication Unit of the Department of Clinical Toxicology CMUJ. Respiratory regulation was evaluated "on line" by means of synchronous measurements of the respiratory pattern (according to Milic-Emili assumptions) and occlusion pressure P 0.1 (according to Whitlaw assumptions). The central respiratory drive (VT/Tin) and the timing component of the breathing cycle (Tin/Ttot) were simillar in both groups of abusers. In comparison to the control group, in the group of opiates abusers, values of VT/Tin were higher during examination performed after treatment, and values of Tin/Ttot were elevated (in group I--only before treatment; in group II--before and after treatment). Examination of respiratory pattern and occlusion pressure is based on recording spontaneous breathing, which this can be performed even in unconscious patients in very early stage of poisoning.
阿片类药物和酒精都是中枢神经系统抑制剂，它们也可能对负责呼吸控制的脑干中枢产生抑制作用。呼吸调节紊乱反映在呼吸效率上。本研究的目的是通过测量阿片类药物和酒精滥用者的呼吸模式和阻断压来评估呼吸调节。共有180人接受检查：84名酒精滥用者（第一组）、36名阿片类药物滥用者（第二组）和40名健康人（对照组）。两组依赖者均在CMUJ临床毒理学系戒毒科接受治疗。通过同步测量呼吸模式（根据米利奇 - 埃米利假设）和阻断压P0.1（根据惠特洛假设）对呼吸调节进行“在线”评估。两组滥用者的中枢呼吸驱动（VT/Tin）和呼吸周期的时间成分（Tin/Ttot）相似。与对照组相比，在阿片类药物滥用者组中，治疗后检查期间VT/Tin的值较高，而Tin/Ttot的值升高（第一组——仅在治疗前；第二组——治疗前后）。呼吸模式和阻断压的检查基于记录自主呼吸，即使在中毒非常早期的无意识患者中也可以进行。
