Golightly K L, Lloyd J A, Hobson J E, Gallagher P, Mercer G, Young A H
School of Neurosciences, Division of Psychiatry, University of Newcastle-upon-Tyne.
Psychol Med. 2001 Jan;31(1):75-84. doi: 10.1017/s0033291799003062.
Brain 5-hydroxytryptamine (5-HT) function is implicated in the pathophysiology of schizophrenia and the action of new generation antipsychotic drugs. By the method of acute tryptophan depletion (ATD) 5-HT can be selectively manipulated. The aim of this study was to examine the effects of ATD on symptoms, mood and cognition in schizophrenic patients.
Twenty-eight schizophrenic patients participated in a within subject, double-blind, placebo-controlled counterbalanced cross-over study. Patients with a concurrent DSM-IV axis I diagnosis were excluded. Symptoms, mood and cognitive function were evaluated following ATD or ingestion of a control drink.
The depleting drink significantly reduced plasma total and free tryptophan. Tryptophan/LNAA ratios did not alter with the administration of the control drink, but differed significantly with ATD; however there was no significant change in tyrosine/LNAA ratio. ATD led to impairment in executive function that was dependent upon the order of administration. Tests of sustained attention, speed of processing, and everyday memory were not affected. No effects were observed on subjective mood ratings, movement disorders or PANSS scores.
Acute tryptophan depletion selectively alters cognition in schizophrenia, but has no effect on symptoms, mood ratings or movement disorders.
脑5-羟色胺（5-HT）功能与精神分裂症的病理生理学及新一代抗精神病药物的作用有关。通过急性色氨酸耗竭（ATD）方法可选择性地调控5-HT。本研究旨在探讨ATD对精神分裂症患者症状、情绪和认知的影响。
28例精神分裂症患者参与了一项自身对照、双盲、安慰剂对照的平衡交叉研究。排除同时患有DSM-IV轴I诊断的患者。在ATD或摄入对照饮料后评估症状、情绪和认知功能。
耗竭饮料显著降低了血浆总色氨酸和游离色氨酸水平。色氨酸/大分子中性氨基酸（LNAA）比值在给予对照饮料后未改变，但在ATD后有显著差异；然而酪氨酸/LNAA比值无显著变化。ATD导致执行功能受损，这取决于给药顺序。持续注意力、加工速度和日常记忆测试未受影响。在主观情绪评分、运动障碍或阳性和阴性症状量表（PANSS）评分上未观察到影响。
急性色氨酸耗竭选择性地改变精神分裂症患者的认知，但对症状、情绪评分或运动障碍无影响。
