Watanabe R, Okamoto S, Asahi A, Mori T, Takayama N, Ikeda Y
Division of Hematology, Department of Internal Medicine, School of Medicine, Keio University.
Rinsho Ketsueki. 2000 Dec;41(12):1285-8.
Idiopathic hyperammonemia (IHA) is a rare but serious complication of stem cell transplantation. We report a patient with immunoblastic lymphoadenopathy-like T-cell lymphoma who developed IHA 10 days after allogeneic bone marrow transplantation from an HLA-matched unrelated donor. Despite intensive supportive care, the patient died due to this metabolic disorder two days later. Being mindful of the possibility of IHA in patients who develop confusion and respiratory alkalosis soon after stem cell transplantation would allow earlier treatment and might improve the chance of survival.
特发性高氨血症（IHA）是干细胞移植罕见但严重的并发症。我们报告了一例免疫母细胞性淋巴结病样T细胞淋巴瘤患者，在接受来自HLA匹配的无关供者的异基因骨髓移植后10天发生了IHA。尽管给予了强化支持治疗，患者仍在两天后因这种代谢紊乱死亡。对于干细胞移植后不久出现意识模糊和呼吸性碱中毒的患者，留意IHA的可能性将有助于早期治疗，并可能提高生存几率。
