一名成人T细胞淋巴瘤患者接受异基因脐血移植后发生供体细胞来源的急性髓系白血病。
Donor cell derived acute myeloid leukemia after allogeneic cord blood transplantation in a patient with adult T-cell lymphoma.
作者信息
Matsunaga Takuya, Murase Kazuyuki, Yoshida Makoto, Fujimi Akihito, Iyama Satoshi, Kuribayashi Kageaki, Sato Tsutomu, Kogawa Katsuhisa, Hirayama Yasuo, Sakamaki Sumio, Kohda Kyuhei, Niitsu Yoshiro
机构信息
Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan.
出版信息
Am J Hematol. 2005 Aug;79(4):294-8. doi: 10.1002/ajh.20349.
We report a patient with adult T-cell lymphoma who developed acute myeloid leukemia (AML) after allogeneic cord blood transplantation (CBT). Fluorescence in situ hybridization (FISH) studies and molecular analysis using short tandem repeat (STR) sequences proved the AML to be of donor origin. Although 25 cases of donor cell leukemia (DCL) occurring after allogeneic bone marrow transplantation have previously been reported, there have been no reports of DCL after CBT. This case is the first-reported DCL patient after CBT.
我们报告了1例成人T细胞淋巴瘤患者，其在异基因脐血移植（CBT）后发生了急性髓系白血病（AML）。荧光原位杂交（FISH）研究以及使用短串联重复序列（STR）进行的分子分析证实该AML源自供体。尽管此前已有25例异基因骨髓移植后发生供体细胞白血病（DCL）的病例报道，但尚无CBT后发生DCL的报道。该病例是首例报道的CBT后DCL患者。
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