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额叶去抑制、雷特综合征与注意力缺陷多动障碍

Frontal lobe disinhibition, Rett syndrome and attention deficit hyperactivity disorder.

作者信息

Niedermeyer E

机构信息

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

出版信息

Clin Electroencephalogr. 2001 Jan;32(1):20-3. doi: 10.1177/155005940103200106.

DOI:10.1177/155005940103200106
PMID:11202137
Abstract

Motor cortex hyperexcitability in Rett Syndrome (RS) has been ascribed to the failure of an inhibiting system arising from the frontal lobes, a system needed in childhood and early adolescence. It is also presumed that, on a virtually dysfunctional (nonstructural) basis, motor cortex hyperexcitability in ADHD is also due to insufficient frontal lobe inhibition ("lazy frontal lobe"). A series of schematic illustrations is added for the sake of easier comprehension of the presented concept.

摘要

雷特综合征(RS)中运动皮层的过度兴奋被归因于额叶产生的抑制系统的功能障碍,该系统在儿童期和青春期早期是必需的。也有人推测,在几乎功能失调(非结构性)的基础上,注意力缺陷多动障碍(ADHD)中运动皮层的过度兴奋也是由于额叶抑制不足(“额叶懒惰”)。为了便于理解所提出的概念,添加了一系列示意图。

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