Petrukhina G N, Kalugin S A, Makarov V A, Gandel' V G
Laboratory of Hemostasis Pathology and Pharmacology, Scientific Hematological Center, Russian Academy of Medical Sciences, Novo-Zykovskii proezd 4a, Moscow, 125167 Russia.
Eksp Klin Farmakol. 2000 Nov-Dec;63(6):30-3.
The chronic oral administration of epaden (a concentrate of n-3 polyunsaturated fatty acids, n-3 PUFA) to rabbits leads to a decrease in activity of the tissue type plasminogen activator (t-PA) in the blood plasma. In order to elucidate the mechanism of this phenomenon, the epinephrine (adrenaline) stimulated t-PA release in rabbits pretreated with epaden for 4 weeks was compared to that in the control (untreated) group. The epinephrine injections led to a reliable, albeit short-time, increase in the t-PA activity in both test and control groups. Although the base activity of t-PA in the epaden-treated group was lower than that in the control group, the t-PA release in the former group was more pronounced. In addition, the t-PA production was induced by the immobilization shock model in rabbits one month after beginning of the epaden administration (animals in the control group were subject to the shock without epaden pretreatment). In this test, the t-PA release was also more intense in the epaden-treated animals. These results indicate that the dietary epaden administration per os reduces the basal t-PA level, but increases the agonist-induced plasminogen activator production.
对兔子长期口服epaden（一种n-3多不饱和脂肪酸，即n-3 PUFA的浓缩物）会导致血浆中组织型纤溶酶原激活剂（t-PA）的活性降低。为了阐明这一现象的机制，将用epaden预处理4周的兔子在肾上腺素刺激下的t-PA释放情况与对照组（未处理）进行了比较。肾上腺素注射导致测试组和对照组的t-PA活性均出现可靠的、尽管是短期的增加。虽然epaden处理组中t-PA的基础活性低于对照组，但前一组中t-PA的释放更为明显。此外，在开始给予epaden一个月后，通过固定应激模型诱导兔子产生t-PA（对照组动物在未进行epaden预处理的情况下遭受应激）。在该测试中，epaden处理的动物中t-PA的释放也更为强烈。这些结果表明，经口给予饮食中的epaden会降低基础t-PA水平，但会增加激动剂诱导的纤溶酶原激活剂的产生。
