Petrukhina G N, Makarov V A, Kalugin S A, Gandel' V G
Eksp Klin Farmakol. 1997 Mar-Apr;60(2):37-41.
Daily oral 6-week administration of epaden in a dose containing 0.3 g eucosopentanoic acid and 0.05 g docosahexaenoic acid caused decrease in collagen-induced platelet aggregation in rabbits in vivo and in the activity of the tissue type plasminogen activator, as well as reduction in the level of antithrombin III cofactor activity. No changes were encountered in ADP-induced aggregation, in the platelet count, in platelet adhesion to collagen, and in activated partial thromboplastin time.
对兔子进行为期6周的每日口服依帕汀给药，剂量为含0.3克二十碳五烯酸和0.05克二十二碳六烯酸，可使家兔体内胶原诱导的血小板聚集减少，组织型纤溶酶原激活剂活性降低，抗凝血酶III辅因子活性水平降低。在ADP诱导的聚集、血小板计数、血小板对胶原的粘附以及活化部分凝血活酶时间方面未发现变化。
