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恶性黑色素瘤患者中O血型和Gm(-1)表型的发生率

On the incidence of blood group O and Gm(-1) phenotypes in patients with malignant melanoma.

作者信息

Walter H, Brachtel R, Hilling M

出版信息

Hum Genet. 1979 May 23;49(1):71-81. doi: 10.1007/BF00277688.

DOI:10.1007/BF00277688
PMID:112031
Abstract

Fifteen polymorphic systems of the blood (ABO, MNSs, Rhesus, P, Kell, Duffy, Kidd, Hp, Gc, Gm, Inv, aP, PGM1, EsD, and 6-PGD) were examined in 191 unrelated male and female patients suffering from malignant melanoma. These polymorphic systems were compared with the corresponding phenotype and gene frequencies of controls from the same geographical area (Rhineland-Palatinate). The only associations discovered were the ABO and Gm polymorphisms: The incidence of O and Gm(-1) phenotypes in patients is obviously higher than in controls. These observations agree with the findings in other population samples from Germany and Bulgaria.

摘要

对191例患恶性黑色素瘤的非亲属男性和女性患者检测了15种血液多态系统(ABO、MNSs、恒河猴、P、凯尔、达菲、基德、Hp、Gc、Gm、Inv、aP、PGM1、EsD和6 - PGD)。将这些多态系统与来自同一地理区域(莱茵兰 - 普法尔茨)的对照的相应表型和基因频率进行了比较。发现的唯一关联是ABO和Gm多态性:患者中O和Gm(-1)表型的发生率明显高于对照。这些观察结果与来自德国和保加利亚的其他人群样本中的发现一致。

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引用本文的文献

1
Familial cutaneous malignant melanoma: autosomal dominant trait possibly linked to the Rh locus.家族性皮肤恶性黑色素瘤:常染色体显性性状可能与Rh基因座有关。
Proc Natl Acad Sci U S A. 1983 Oct;80(19):6071-5. doi: 10.1073/pnas.80.19.6071.

本文引用的文献

1
On estimating the relation between blood group and disease.关于评估血型与疾病之间的关系。
Ann Hum Genet. 1955 Jun;19(4):251-3. doi: 10.1111/j.1469-1809.1955.tb01348.x.
2
Serogenetic investigations on malignant melanomas with reference to the incidence of ABO system, Rh system, Gm, Inv, Hp and Ge systems.关于恶性黑色素瘤的血清遗传学研究,涉及ABO系统、Rh系统、Gm、Inv、Hp和Ge系统的发生率。
Humangenetik. 1972;15(3):227-31. doi: 10.1007/BF00702356.
3
Blood groups in patients with malignant melanoma of the skin.皮肤恶性黑色素瘤患者的血型
Tumori. 1974 Sep-Oct;60(5):361-3. doi: 10.1177/030089167406000502.
4
Gm(1) and Gm(2) immunoglobulin allotypes in patients with malignant melanoma.恶性黑色素瘤患者中的Gm(1)和Gm(2)免疫球蛋白同种异型
Humangenetik. 1975 Jul 23;28(3):177-81. doi: 10.1007/BF00278542.
5
[Clinic, statistic and risik factors of the malignant melanoma (author's transl)].恶性黑色素瘤的临床、统计学及风险因素(作者译)
Dermatologica. 1977;155(3):129-42.
6
Psoriasis vulgaris and genetic markers.寻常型银屑病与遗传标记
Hum Genet. 1977 Jun 30;37(2):169-81. doi: 10.1007/BF00393580.
7
[Melanoma and sun rays].[黑色素瘤与阳光]
Dtsch Med Wochenschr. 1978 Jul 21;103(29):1155-6. doi: 10.1055/s-0028-1129219.