Brachtel R, Walter H, Beck W, Hilling M
Hum Genet. 1979 Jul 18;49(3):337-48. doi: 10.1007/BF00569354.
In 239 German patients with atopic conditions (atopic dermatitis, hay fever, allergic rhinitis, bronchial asthma, and acute urticaria) the phenotype and gene distribution of 15 genetic blood polymorphisms (ABO, MNSs, rhesus, P, Kell, Duffy, Kidd, Hp, Gc, Gm, Inv, aP, PGM1, EsD, and 6-PGD) were analyzed and compared with those in 151 selected controls (individuals clinically free of allergic conditions and without allergy in the family history). The incidence of blood group antigens A and B was somewhat higher in patients than in controls. These observations are in accordance with the results of previous studies in other populations. In addition, our observations favor the hypothesis that there are also associations between the phenotypes Jk (a-b+), Inv(1) and red cell acid phosphatase aP A and aP AP on the one hand and atopic disposition on the other. The possible reasons for these associations are discussed.
对239名患有特应性疾病（特应性皮炎、花粉症、过敏性鼻炎、支气管哮喘和急性荨麻疹）的德国患者，分析了15种遗传血型多态性（ABO、MNSs、恒河猴血型、P、凯尔血型、达菲血型、基德血型、触珠蛋白、维生素D结合蛋白、免疫球蛋白重链、异凝集素、酸性磷酸酶、磷酸葡萄糖变位酶1、酯酶D和6 - 磷酸葡萄糖脱氢酶）的表型和基因分布，并与151名选定的对照者（临床上无过敏疾病且家族史中无过敏的个体）进行比较。患者中血型抗原A和B的发生率略高于对照者。这些观察结果与先前在其他人群中的研究结果一致。此外，我们的观察结果支持这样一种假说，即一方面Jk（a - b +）、异凝集素（1）表型以及红细胞酸性磷酸酶aP A和aP AP与另一方面的特应性倾向之间也存在关联。讨论了这些关联的可能原因。
