Kleszczyńska H, Sarapuk J, Oświ cimska M, Witek S
Department of Physics and Biophysics, Agricultural University, Wrocław, Poland.
Z Naturforsch C J Biosci. 2000 Nov-Dec;55(11-12):976-80. doi: 10.1515/znc-2000-11-1221.
The antioxidative activity of two series of amphiphilic compounds from a group of quaternary ammonium salts has been investigated. They were so-called bifunctional surfactants synthesized to be used as common pesticides or as antioxidants. The latter application was to be ensured by providing the compounds studied with an antioxidant group. Studies on antioxidative possibilities of those compounds were performed on pig erythrocytes. Due to their hydrophobic parts, they anchor in the erythrocyte membrane and influence the degree of lipid oxidation in the erythrocyte membrane subjected to UV radiation. It was found that compounds of both series decreased the oxidation of the membrane lipids. The inhibition of this oxidation increased with the length of their hydrophobic chains up to fourteen carbon atoms. The compounds of the longest hydrophobic chains showed a somewhat weaker antioxidative activity. Of the two series studied compounds were more effective having bromide ions as counterions. The corresponding compounds of a second series (chlorides) protected erythrocyte significantly weaker against oxidation. The effect of the compounds on fluidity of the erythrocyte membrane has been studied in order to explain the oxidation results. Change in fluidity of the erythrocyte ghost membranes was found also dependent on length of the hydrophobic part of the compounds and was more pronounced in the case of bromide surfactants. The final conclusion is that the compounds studied can be succesfully used as antioxidant agents of good efficacy.
对一组季铵盐类两亲化合物的抗氧化活性进行了研究。它们是所谓的双功能表面活性剂，合成后可用作普通农药或抗氧化剂。通过为所研究的化合物提供一个抗氧化基团来确保后一种应用。对这些化合物的抗氧化可能性的研究是在猪红细胞上进行的。由于其疏水部分，它们锚定在红细胞膜中，并影响受到紫外线辐射的红细胞膜中的脂质氧化程度。发现两个系列的化合物都降低了膜脂质的氧化。这种氧化的抑制作用随着其疏水链长度增加到十四个碳原子而增强。具有最长疏水链的化合物表现出稍弱的抗氧化活性。在所研究的两个系列中，以溴离子作为抗衡离子的化合物更有效。第二个系列（氯化物）的相应化合物对红细胞氧化的保护作用明显较弱。为了解释氧化结果，研究了这些化合物对红细胞膜流动性的影响。发现红细胞血影膜流动性的变化也取决于化合物疏水部分的长度，并且在溴化物表面活性剂的情况下更为明显。最终结论是，所研究的化合物可以成功地用作高效抗氧化剂。
