Kleszcyńska H, Oświecimska M, Witek S, Przestalski S
Department of Physics and Biophysics, Agricultural University, Wrocław, Poland.
Z Naturforsch C J Biosci. 1998 May-Jun;53(5-6):425-30. doi: 10.1515/znc-1998-5-620.
The antioxidant activity of five new compounds from a group of quaternary ammonium salts with antioxidant function has been investigated. The effect of the compounds on the degree of lipid oxidation in the erythrocyte membrane subjected to UV radiation was studied. It was found that all the salts used decreased oxidation of the lipids in the erythrocyte membrane. The antioxidant activity of the ammonium salts studied increased with their alkyl chain length. Three compounds with the longest alkyl chains were the most active antioxidants, and their antioxidant properties were comparable to those of a flavonoid extracted from hawthorn. The antioxidant effectiveness of the ten-carbon alkyl chain compound was comparable with that of the known antioxidant 3,5-di-t-butyl-4-hydroxytoluene (BHT). The least effective antioxidant studied proved to be the eight-carbon alkyl chain compound. The effect of these compounds on fluidity of the erythrocyte membrane has been studied, and for all an increase of fluidity of the membrane was observed. The changes in erythrocyte ghosts fluidity depended both on concentration and type of compound. A fluorimetric study also indicated that rigidity of the erythrocyte membrane increased with degree of its oxidation, but with antioxidants present membrane rigidity increased less.
对一组具有抗氧化功能的季铵盐中的五种新化合物的抗氧化活性进行了研究。研究了这些化合物对经紫外线辐射的红细胞膜脂质氧化程度的影响。发现所有使用的盐都降低了红细胞膜中脂质的氧化。所研究的铵盐的抗氧化活性随其烷基链长度的增加而增强。具有最长烷基链的三种化合物是最具活性的抗氧化剂，其抗氧化性能与从山楂中提取的黄酮类化合物相当。具有十碳烷基链的化合物的抗氧化效果与已知抗氧化剂3,5-二叔丁基-4-羟基甲苯（BHT）相当。所研究的最无效的抗氧化剂是具有八碳烷基链的化合物。研究了这些化合物对红细胞膜流动性的影响，发现所有化合物都使膜的流动性增加。红细胞血影流动性的变化取决于化合物的浓度和类型。荧光研究还表明，红细胞膜的刚性随其氧化程度的增加而增加，但存在抗氧化剂时膜刚性的增加较少。
