通过与肝匀浆和肝微粒体孵育对12,13 - 环氧 - 11 - 羟基 - 9 - 十八碳烯酸和4,5 - 环氧 - N - 乙酰鞘氨醇进行转化。
Transformations of 12,13-epoxy-11-hydroxy-9-octadecenoic acid and 4,5-epoxy-N-acetylsphingosine by incubation with liver homogenate and liver microsomes.
作者信息
Möllenberg A, Spiteller G
机构信息
Institut für Organische Chemie I, Universität Bayreuth, Germany.
出版信息
Z Naturforsch C J Biosci. 2000 Nov-Dec;55(11-12):981-6. doi: 10.1515/znc-2000-11-1222.
PMID:11204206
Abstract
Transformation of 12,13-epoxy-11-hydroxy-9-octadecenoic acid and 4,5-epoxy-N-acetylsphingosine by addition of porcine liver homogenate and human liver microsomes, respectively was investigated. Both epoxides were converted to corresponding dioles by porcine liver homogenate, but not by human liver microsomes, suggesting location of the hydrolyzing enzymes not in the microsomes, but within the cell wall.
摘要
分别通过添加猪肝匀浆和人肝微粒体，对12,13-环氧-11-羟基-9-十八碳烯酸和4,5-环氧-N-乙酰鞘氨醇的转化进行了研究。两种环氧化物均可被猪肝匀浆转化为相应的二醇，但人肝微粒体则不能，这表明水解酶的位置不在微粒体中，而是在细胞壁内。
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