Kuch B, Gneiting B, Döring A, Muscholl M, Bröckel U, Schunkert H, Hense H W
Institut für Epidemiologie und Sozialmedizin, Bereich Klinische Epidemiologie, University of Münster, Germany.
J Hypertens. 2001 Jan;19(1):135-42. doi: 10.1097/00004872-200101000-00018.
Indexation to fat-free mass (FFM) seems to be the best option for adjusting left ventricular (LV) mass. However, measurements of FFM are frequently not available.
To define the relation of FFM with commonly available anthropometric measures in order to derive an approximation formula of FFM that can be used for valid indexation of LV mass.
A total of 1,371 subjects from a community survey were examined by echocardiography to measure LV mass and by bioelectrical impedance analyses (BIA) for the determination of FFM. An approximation of FFM was generated in a healthy subgroup of 213 men and 291 women by non-linear regression techniques.
Compared with body height, height2.0, height2.7, (the superscripts following weight and height are raised powers used as a more appropriate method for indexing LV mass) or body surface area, FFM measured by BIA in the healthy subgroups was best predicted by gender-specific equations of the form: FFM = 5.1 x height1.14 x weight0.41 for men and FFM = 5.34 x height1.47 x weight0.33 for women. In the healthy reference group, indexation of LV mass for BIA-determined FFM and approximated FFM (FFMa), respectively, equally eliminated gender differences in LV mass and markedly reduced the influence of body mass index without affecting the associations between blood pressure and LV mass. Validation of FFMa in two independent population-based samples, aged 52 to 67 years, of the same source population confirmed that LV mass indexed by FFMa produced results that were highly consistent with those obtained with indexation by BIA-determined FFM.
We propose a novel approximation of FFM based on exponentials of body height and weight. It performed well in the indexation of LV mass in middle-aged men and women of this study. Evaluation of the equation in other populations should be awaited before its use is recommended in situations where direct determination of FFM is not possible.
以去脂体重（FFM）进行指数化似乎是调整左心室（LV）质量的最佳选择。然而，FFM的测量常常无法获得。
确定FFM与常用人体测量指标之间的关系，以便得出可用于有效指数化LV质量的FFM近似公式。
对社区调查中的1371名对象进行超声心动图检查以测量LV质量，并通过生物电阻抗分析（BIA）来测定FFM。通过非线性回归技术在213名男性和291名女性组成的健康亚组中生成FFM的近似值。
与身高、身高².⁰、身高².⁷（体重和身高后的上标为用作更合适的LV质量指数化方法的幂次）或体表面积相比，健康亚组中通过BIA测量的FFM由以下特定性别的公式能得到最佳预测：男性为FFM = 5.1×身高¹.¹⁴×体重⁰.⁴¹，女性为FFM = 5.34×身高¹.⁴⁷×体重⁰.³³。在健康参考组中，分别以BIA测定的FFM和近似FFM（FFMa）对LV质量进行指数化，同样消除了LV质量的性别差异，并显著降低了体重指数的影响，同时不影响血压与LV质量之间的关联。在来自同一源人群的两个独立的基于人群的样本（年龄52至67岁）中对FFMa进行验证，结果证实以FFMa指数化的LV质量产生的结果与以BIA测定的FFM进行指数化所获得的结果高度一致。
我们提出了一种基于身高和体重指数的新型FFM近似值。在本研究的中年男性和女性中，它在LV质量指数化方面表现良好。在推荐其用于无法直接测定FFM的情况之前，应等待该公式在其他人群中的评估结果。
