[降钙素原在儿童化脓性和无菌性脑膜炎诊断中的应用]

[Procalcitonin in diagnosis of purulent and aseptic meningitis in children].

作者信息

Korczowski B, Bijoś A, Rybak A

机构信息

Oddziału Dzieciecego Szpitala Wojewódzikego nr 2 w Rzeszowie.

出版信息

Pol Merkur Lekarski. 2000 Nov;9(53):755-7.

PMID:11204322

Abstract

UNLABELLED

Procalcitonin (PCT) is a new indicator of the systemic response to severe infections. To evaluate clinical usefulness of serum procalcitonin measurements in the differential diagnosis of purulent versus aseptic meningitis in children was the aim of the study. Fifteen children (aged 1 month-14 years) with purulent meningitis and 12 children (aged 6 months-12 years) with aseptic meningitis were included into the study. Serum PCT concentration was measured on admission by immunoluminometric assay. Thirty healthy controls (aged 3 months-14 years) were also enrolled into the study. Serum PCT concentration was above 0.5 ng/ml in 14 out of 15 children with purulent meningitis (range 0.0-95.2 ng/ml; arrhythmetic mean--28.2 ng/ml). In all children with aseptic meningitis (range 0.0-0.3 ng/ml; mean--0.1 ng/ml) as well as in healthy controls (range 0.0-0.3 ng/ml; mean--0.1 ng/ml) serum PCT was below 0.5 ng/ml.

CONCLUSION

Elevated serum PCT concentration in child with meningitis suggests bacterial aetiology.

摘要

未标注

降钙素原（PCT）是一种反映全身对严重感染反应的新指标。本研究旨在评估血清降钙素原检测在儿童化脓性脑膜炎与无菌性脑膜炎鉴别诊断中的临床应用价值。本研究纳入了15例（年龄1个月至14岁）化脓性脑膜炎患儿和12例（年龄6个月至12岁）无菌性脑膜炎患儿。入院时采用免疫发光分析法测定血清PCT浓度。还纳入了30名健康对照者（年龄3个月至14岁）。15例化脓性脑膜炎患儿中有14例血清PCT浓度高于0.5 ng/ml（范围0.0 - 95.2 ng/ml；算术平均值 - 28.2 ng/ml）。所有无菌性脑膜炎患儿（范围0.0 - 0.3 ng/ml；平均值 - 0.1 ng/ml）以及健康对照者（范围0.0 - 0.3 ng/ml；平均值 - 0.1 ng/ml）血清PCT均低于0.5 ng/ml。