Jarosz M, Dzieniszewski J
Kliniki Chorób Metabolicznych i Gastroenterologii Instytutu Zywności i Zywienia w Warszawie.
Pol Merkur Lekarski. 2000 Nov;9(53):795-8.
The paper overviews food-drug interactions. The part 2 reviews the interactions of foods with the drugs which occur at the level of metabolism. Concomitant intake with food increases or decreases the concentrations of many agents in humans. The effect seems to be mediated mainly by suppression of the cytochrome P450 in the liver and in the small intestine wall. This results in a diminished first pass metabolism with higher bioavailability and increased maximal concentrations of substrates of this enzyme. To avoid the interactions many drugs should not be taken with the meal and citrus juices, particularly grapefruit juice.
本文概述了食物与药物的相互作用。第二部分回顾了食物与药物在代谢水平上的相互作用。与食物同时摄入会增加或降低人体内许多药物的浓度。这种影响似乎主要是由肝脏和小肠壁中细胞色素P450的抑制介导的。这导致首过代谢减弱，生物利用度更高，该酶底物的最大浓度增加。为避免相互作用，许多药物不应与餐食和柑橘汁一起服用，尤其是葡萄柚汁。
