Tsai S J, Wang Y C, Hong C J
Department of Psychiatry, Veterans General Hospital-Taipei, Taiwan.
Psychiatr Genet. 2000 Sep;10(3):149-51. doi: 10.1097/00041444-200010030-00008.
Cannabis can induce schizophrenic-like symptoms in healthy individuals. A principal active ingredient of cannabis, delta-9-tetrahydrocannabinol, acts in the brain on a specific receptor, termed the cannabinoid receptor 1 (CNR1). The human gene for CNR1 is mapped to chromosome 6q14-15, and linkage studies have produced evidence for a schizophrenia-susceptibility locus in this region. To explore a possible role for CNR1 in the pathogenesis of schizophrenic disorders, we used an association study to genotype the CNR1 polymorphism for 127 schizophrenic patients and 146 control subjects. The results demonstrate no association between CNR1 genotypes and schizophrenic disorders (P = 0.409), with these negative findings suggesting that, for Chinese populations, the (AAT)n triplet repeat in the promoter region of the CNR1 gene is not directly involved in the pathogenesis of schizophrenic disorders.
大麻可在健康个体中诱发类似精神分裂症的症状。大麻的一种主要活性成分，Δ-9-四氢大麻酚，在大脑中作用于一种特定受体，称为大麻素受体1（CNR1）。人类CNR1基因定位于染色体6q14 - 15，连锁研究已为该区域存在精神分裂症易感基因座提供了证据。为了探究CNR1在精神分裂症发病机制中的可能作用，我们采用关联研究对127例精神分裂症患者和146例对照受试者的CNR1基因多态性进行基因分型。结果表明CNR1基因型与精神分裂症之间无关联（P = 0.409），这些阴性结果提示，对于中国人群，CNR1基因启动子区域的（AAT）n三联体重复不直接参与精神分裂症的发病机制。
