Barbato M, Miglietta M R, Viola F, Uccini S, Bosco S, Dito L, Lo Russo L, Formisano M, Lucarelli S, Frediani T, Cardi E
Servizio Speciale di Gastroenterologia, Istituto Clinica Pediatrica, Università La Sapienza, Roma.
Minerva Pediatr. 2000 Nov;52(11):617-21.
The term latent coeliac disease (CD) is applied to patients who were previously shown to have a normal jejunal mucosa on a free diet. The aim of this study was to determine whether a high AGA value in the serum of patients with coeliac symptoms can also be regarded by itself, without typical mucosal atrophy, as a marker of latent CD, as some authors suggest in relatives of celiac patients.
We observed 31 patients with suspected CD and pathological values of serum IgA ang IgG AGA. In all we performed intestinal biopsy, assayed antiendomisium antibodies (AEA) in serum, AGA IgA, IgG, and IgM in duodenal jejunal fluid and in some of the lymphocytcs CD3+ gamma/delta+ in the lamina propria of the intestinal mucosa.
In this study only pathological values of serum AGA without mucosa atrophy don't seem to be markers of latent CD, but an aspecific allergic response.
As shown by other authors serum AEA, intestinal fluid AGA IgM and lamina propria lymphocytes CD3+ gamma/delta+ seem markers of latent CD.
潜在性乳糜泻（CD）这一术语适用于那些先前在自由饮食情况下空肠黏膜显示正常的患者。本研究的目的是确定，正如一些作者在乳糜泻患者亲属研究中所提出的那样，有乳糜泻症状患者血清中抗谷蛋白抗体（AGA）值升高，在无典型黏膜萎缩的情况下，其本身是否也可被视为潜在性乳糜泻的一个标志物。
我们观察了31例疑似乳糜泻且血清IgA和IgG AGA值异常的患者。我们对所有患者进行了肠道活检，检测血清中的抗内膜抗体（AEA）、十二指肠空肠液中的AGA IgA、IgG和IgM，以及部分患者肠黏膜固有层中的淋巴细胞CD3 + γ/δ +。
在本研究中，仅血清AGA值异常而无黏膜萎缩似乎并非潜在性乳糜泻的标志物，而是一种非特异性过敏反应。
正如其他作者所表明的，血清AEA、肠液AGA IgM和固有层淋巴细胞CD3 + γ/δ +似乎是潜在性乳糜泻的标志物。
