Bottaro G, Rotolo N, Spina M, Sciuto C, Castiglione S, Sanfilippo G, Musumeci S
I Clinica Pediatrica, Università degli Studi, Catania.
Minerva Pediatr. 1995 Dec;47(12):505-10.
A retrospective study with the aim of evaluating sensitivity and specificity of antigliadin antibodies (AGA) was carried out. AGA values, IgA and IgG, and mucosal damage at intestinal biopsy were compared in each subject, on a sample of 245 subjects, who had undergone intestinal biopsy because of suspected coeliac disease (CD), from January 1991 to December 1993. 130 subjects (53.1%) were found to be suffering from CD, whereas the remaining 115 subjects (46.9%), who did not show any signs of the disease, were considered as controls. When we compared AGA values with mucosal damage we observed that IgA were normal in 24 (18.5%) and pathological in 106 (81.5%) coeliac patients, whereas they were normal in 107 (93%) and pathological in 8 (7%) controls. IgG values were normal in 17 (13.1%) and pathological in 113 (86.9%) coeliac patients, but normal in 75 (65.2%) and pathological in 40 (34.8%) controls. Data about AGA sensitivity related to age, showed IgA sensitivity varying from 80.4% in children under 1 year old to 70% in children over 10 years old and IgG sensitivity from 94.1% to 50%. Data about specificity related to age, showed IgA sensitivity varying from 78.7% in children under 1 year old to 100% in children over 10 years old and IgG specificity from 30.4% to 90.9%. Our results indicated that AGA-IgA had a total sensitivity or 81.5%, a total specificity of 93% and a concordance with intestinal damage of 86.9% while AGA-IgG had a total sensitivity of 86.9%, a total specificity of 65.2% and a concordance with intestinal damage of 76.7%. These data presented a modification on the basis of age, being higher in children under 3 years of age and decreasing with the increase in age. We conclude that AGA have great importance in suspect CD, but it is most important that their results are evaluated on the basis of age.
开展了一项回顾性研究，旨在评估抗麦醇溶蛋白抗体（AGA）的敏感性和特异性。对1991年1月至1993年12月期间因疑似乳糜泻（CD）接受肠道活检的245名受试者样本中的每位受试者，比较了AGA值（IgA和IgG）以及肠道活检时的黏膜损伤情况。发现130名受试者（53.1%）患有CD，而其余115名未表现出任何疾病迹象的受试者（46.9%）被视为对照。当我们将AGA值与黏膜损伤情况进行比较时，观察到在乳糜泻患者中，IgA正常的有24名（18.5%），异常的有106名（81.5%）；而在对照中，IgA正常的有107名（93%），异常的有8名（7%）。IgG值在乳糜泻患者中正常的有17名（13.1%），异常的有113名（86.9%）；但在对照中，正常的有75名（65.2%），异常的有40名（34.8%）。与年龄相关的AGA敏感性数据显示，IgA敏感性在1岁以下儿童中为80.4%，在10岁以上儿童中为70%；IgG敏感性从94.1%至50%不等。与年龄相关的特异性数据显示，IgA敏感性在1岁以下儿童中为78.7%，在10岁以上儿童中为100%；IgG特异性从30.4%至90.9%不等。我们的结果表明，AGA-IgA的总敏感性为81.5%，总特异性为93%，与肠道损伤的一致性为86.9%；而AGA-IgG的总敏感性为86.9%，总特异性为65.2%，与肠道损伤的一致性为76.7%。这些数据随年龄有所变化，在3岁以下儿童中较高，随年龄增长而降低。我们得出结论，AGA在疑似CD中具有重要意义，但最重要的是应根据年龄对其结果进行评估。
