Davies J A, Schwalbach L M
Equine Veterinary Practice, Shelbyville, KY 40066, USA.
J S Afr Vet Assoc. 2000 Sep;71(3):144-7. doi: 10.4102/jsava.v71i3.703.
The efficacy of ivermectin, fenbendazole, pyrantel pamoate and doramectin was evaluated under field conditions at 2 sites in the Free State Province of South Africa. The study involved 25 horses at each site, divided into 5 groups of equal size. Ivermectin, fenbendazole and pyrantel pamoate were administered orally at doses of 0.2, 10 and 19 mg/kg respectively. Doramectin was administered by intramuscular injection at a dose of 0.2 mg/kg. Treatment efficacy was based on the mean faecal egg count reduction 14 days post treatment. At site A a faecal egg count reduction of 100% was found after treatment with ivermectin, fenbendazole and doramectin. A 96.1% reduction was found after treatment with pyrantel pamoate. At site B ivermectin and doramectin produced a 100% reduction in faecal egg counts, fenbendazole produced an 80.8% reduction and pyrantel pamoate a 94.1% reduction. Doramectin produced a 100% reduction in faecal egg counts at both sites, despite not being registered for use in horses. In addition, the results indicated reduced efficacy of fenbendazole at site B, which suggested benzimidazole resistance. Larval cultures showed that cyathostomes accounted for between 86 and 96% of pre-treatment parasite burdens at both sites. Other helminths identified in the faecal samples were Strongylus spp. and Trichostrongylus axei.
在南非自由邦省的两个地点，于野外条件下评估了伊维菌素、芬苯达唑、噻嘧啶和多拉菌素的疗效。该研究在每个地点涉及25匹马，分为5组，每组大小相等。伊维菌素、芬苯达唑和噻嘧啶分别以0.2、10和19mg/kg的剂量口服给药。多拉菌素通过肌肉注射给药，剂量为0.2mg/kg。治疗效果基于治疗后14天粪便虫卵计数的平均降低情况。在A地点，用伊维菌素、芬苯达唑和多拉菌素治疗后粪便虫卵计数降低了100%。用噻嘧啶治疗后降低了96.1%。在B地点，伊维菌素和多拉菌素使粪便虫卵计数降低了100%，芬苯达唑降低了80.8%，噻嘧啶降低了94.1%。尽管多拉菌素未注册用于马匹，但在两个地点都使粪便虫卵计数降低了100%。此外，结果表明芬苯达唑在B地点的疗效降低，这表明存在苯并咪唑耐药性。幼虫培养显示，在两个地点，圆线虫在治疗前寄生虫负荷中占86%至96%。在粪便样本中鉴定出的其他蠕虫为圆线虫属和奥氏类圆线虫。
