Lumsden G G, Quan-Taylor R, Smith S M, Washbrooke I M
Royal (Dick) School of Veterinary Studies, Summerhall, Edinburgh.
Vet Rec. 1989 Nov 11;125(20):497-9. doi: 10.1136/vr.125.20.497.
Three anthelmintic pastes were compared in terms of their ability to suppress the output of parasite eggs in the faeces of 108 grazing horses at four sites in Britain; the horses were treated once with either ivermectin, fenbendazole or pyrantel. At each site, the horses grazed together throughout the trials which took place during the summers of 1985 and 1986. The median periods before parasite eggs reappeared in faeces were 70 days for ivermectin, 14 days for fenbendazole and 39 days for pyrantel embonate. Geometric mean faecal egg counts in the groups treated with ivermectin and pyrantel were significantly less (P less than 0.05) than in the fenbendazole group on days 21, 28, 35 and 42 after treatment. On days 49, 56, 63 and 70 the mean egg counts in the ivermectin group were significantly lower (P less than 0.05) than those in either of the other groups. The results indicated that in order to ensure minimal contamination of pastures, grazing horses treated with ivermectin paste would have required a second treatment approximately 10 weeks after the first, and to achieve similar control with fenbendazole or pyrantel embonate, a second treatment would have been required after approximately two weeks and six weeks, respectively.
在英国四个地点，对三种驱虫膏抑制108匹放牧马粪便中寄生虫卵排出的能力进行了比较；这些马分别用伊维菌素、芬苯达唑或噻嘧啶进行了一次治疗。在每个地点，整个试验期间马群一起放牧，试验于1985年和1986年夏天进行。粪便中再次出现寄生虫卵的中位时间，伊维菌素组为70天，芬苯达唑组为14天，双羟萘酸噻嘧啶组为39天。在治疗后第21、28、35和42天，伊维菌素组和噻嘧啶组的粪便虫卵几何平均计数显著低于芬苯达唑组（P<0.05）。在第49、56、63和70天，伊维菌素组的平均虫卵计数显著低于其他两组中的任何一组（P<0.05）。结果表明，为确保牧场污染最小化，用伊维菌素膏剂治疗的放牧马在首次治疗后约10周需要进行第二次治疗，而用芬苯达唑或双羟萘酸噻嘧啶达到类似的控制效果，则分别需要在约两周和六周后进行第二次治疗。
