Sakamoto S, Okayasu I, Iida K, Fujita K, Yarimizu T, Nagasawa H
Medical Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Anticancer Res. 2000 Nov-Dec;20(6B):4295-9.
Polysaccharides extracted from human tubercle bacilli (specific substance of Maruyama) have been clinically applied in patients with malignant diseases in Japan and other countries. It is known that increased colorectal carcinogenesis occurs in patients with ulcerative colitis. The repeated mucosal necrosis-regeneration sequence in chronic ulcerative colitis induced with 3 % dextran sulfate sodium led to colorectal carcinogenesis in azoxymethane-pretreated mice. Simultaneously multiple injections with the polysaccharides reduced the increases in thymidylate synthase and thymidine kinase activities and a number of bromodeoxyuridine-incorporated S-phase cells in colorectal tissues resulted in the reduction of tumorous regions with high-grade dysplasia.
从人结核杆菌中提取的多糖（丸山氏特异性物质）已在日本和其他国家临床应用于恶性疾病患者。已知溃疡性结肠炎患者的结直肠癌发生增加。用3%硫酸葡聚糖钠诱导的慢性溃疡性结肠炎中反复出现的黏膜坏死-再生序列导致了经乙基亚硝脲预处理的小鼠发生结直肠癌。同时多次注射该多糖可降低胸苷酸合成酶和胸苷激酶活性的增加，并且结直肠组织中许多掺入溴脱氧尿苷的S期细胞减少，导致高级别发育异常的肿瘤区域减少。
