Mitamura T, Sakamoto S, Suzuki S, Yoshimura S, Maemura M, Kudo H
Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Oncol Rep. 2000 May-Jun;7(3):599-601. doi: 10.3892/or.7.3.599.
Lentinan; i.e., polysaccharides extracted from a kind of black mushroom shiitake, has been clinically applied as an antitumor and antimetastatic drug, and has been reported to prevent both chemical and viral carcinogenesis. It is known that lentinan affects the tumorous vascular system resulting in the induction of hemorrhagic necrosis which is dependent on T-cells in the tumor. Repeated mucosal necrosis-regeneration sequence in chronic ulcerative colitis induced with 3% dextran sulfate sodium led to colorectal carcinogenesis in azoxymethane-pretreated mice. In the present study, the additive treatment with lentinan in the azoxymethane-dextran sulfate sodium treated mice enhanced the colorectal high-grade dysplasia, though not significantly, and the splenic weight. This may show the proliferation of pathogenic splenic T cells resulting in a change for the worse of ulcerative colitis, anemia induced with hemorrhage and colorectal carcinogenesis; i.e., high-grade dysplasia of the mucosa and/or invasive adenocarcinomas of the colorectum. The present results may recommend chemoimmunotherapy while using lentinan, but not immunotherapy using lentinan alone, is indicated for the management of cancer patients.
香菇多糖；即从一种黑色香菇中提取的多糖，已作为抗肿瘤和抗转移药物在临床上应用，并且据报道可预防化学致癌和病毒致癌。已知香菇多糖会影响肿瘤血管系统，导致出血性坏死的诱导，这依赖于肿瘤中的T细胞。用3%硫酸葡聚糖钠诱导的慢性溃疡性结肠炎中反复出现的黏膜坏死-再生序列导致了经氧化偶氮甲烷预处理的小鼠发生结直肠癌。在本研究中，在经氧化偶氮甲烷-硫酸葡聚糖钠处理的小鼠中添加香菇多糖治疗虽未显著增强结直肠高级别发育异常，但增加了脾脏重量。这可能表明致病性脾脏T细胞增殖，导致溃疡性结肠炎、出血性贫血和结直肠癌发生恶化；即黏膜高级别发育异常和/或结直肠癌浸润性腺癌。目前的结果可能提示在使用香菇多糖时推荐进行化学免疫治疗，但不建议单独使用香菇多糖进行免疫治疗来管理癌症患者。
