Blackwell S C, Moldenhauer J, Redman M, Hassan S S, Wolfe H M, Berry S M
Department of Obstetrics and Gynecology, Hutzel Hospital, Wayne State University, Detroit, MI 48201, USA.
Arch Gynecol Obstet. 2001 Jan;264(4):191-3. doi: 10.1007/s004040000106.
To determine whether there is a difference in acid-base status at the time of cordocentesis between fetuses with symmetric and asymmetric intrauterine growth restriction (IUGR).
Non-anomalous singleton fetuses with IUGR who underwent fetal blood sampling for rapid karyotype analysis from 1992-1995 were retrospectively identified. Cases with gestational age <24 weeks, abnormal karyotype, or evidence of congenital infection were excluded. Fetuses were divided into two groups based on Head Circumference/ Abdominal Circumference Ratio (HC/AC). The asymmetric-IUGR group had HC/AC > or = 95% tile for GA, and the symmetric-IUGR group had HC/AC <95% tile. GA adjusted values of umbilical venous pH, pCO2, pO2, HCO3, hemoglobin and reticulocyte count were calculated by subtracting the mean values for GA from the observed and compared between groups.
Both symmetric-IUGR (n = 7) and asymmetric-IUGR (n = 9) had umbilical venous pH and pO2, levels lower than GA normative values. However, there were no differences between groups for any of the parameters studied.
Fetuses with symmetric and asymmetric IUGR due to UPI display a similar degree of acid-base impairment.
确定对称型和非对称型宫内生长受限（IUGR）胎儿在脐血穿刺时的酸碱状态是否存在差异。
回顾性纳入1992年至1995年间因快速核型分析而接受胎儿血样采集的非畸形单胎IUGR胎儿。排除孕周<24周、核型异常或有先天性感染证据的病例。根据头围/腹围比值（HC/AC）将胎儿分为两组。非对称型IUGR组的HC/AC大于或等于相应孕周的第95百分位数，对称型IUGR组的HC/AC小于第95百分位数。通过从观察值中减去相应孕周的平均值来计算脐静脉pH值、pCO2、pO2、HCO3、血红蛋白和网织红细胞计数的孕周校正值，并在两组之间进行比较。
对称型IUGR（n = 7）和非对称型IUGR（n = 9）的脐静脉pH值和pO2水平均低于相应孕周的正常范围值。然而，所研究的任何参数在两组之间均无差异。
由于子宫胎盘功能不全导致的对称型和非对称型IUGR胎儿表现出相似程度的酸碱平衡损害。
