Yamashita R A, Sellers J R, Anderson J B
Laboratory of Molecular Cardiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
J Muscle Res Cell Motil. 2000;21(6):491-505. doi: 10.1023/a:1026589626422.
The recent sequencing of the genome of Drosophila melanogaster has provided a valuable resource for mining the database for genes of interest. We took advantage of this opportunity in an attempt to identify novel myosins in Drosophila and confirm the presence of the previously identified myosins from classes I, II, III, V, VI, and VII. The Drosophila database annotators predicted the structure of three additional proteins which we identified as novel unconventional myosins, two of which fell into classes XV and XVIII, respectively. Our own efforts predicted the presence of four additional partial sequences that appear to be myosin proteins which did not fall into any specific class. In the future comparative genomics will hopefully lead to the placement of these myosins into new classes.
黑腹果蝇基因组的近期测序为挖掘感兴趣的基因数据库提供了宝贵资源。我们利用这一机会试图在果蝇中鉴定新型肌球蛋白，并确认先前鉴定出的来自I、II、III、V、VI和VII类的肌球蛋白的存在。果蝇数据库注释者预测了另外三种蛋白质的结构，我们将其鉴定为新型非常规肌球蛋白，其中两种分别属于XV和XVIII类。我们自己的研究预测还存在另外四个部分序列，它们似乎是肌球蛋白蛋白，但不属于任何特定类别。未来，比较基因组学有望将这些肌球蛋白归入新的类别。
