根据美国糖尿病协会（ADA）和国家糖尿病数据组（NDDG）标准定义的糖尿病组具有相似的有氧能力、血压和身体组成。美国糖尿病协会和国家糖尿病数据组。

Diabetic groups as defined by ADA and NDDG criteria have a similar aerobic capacity, blood pressure and body composition. American Diabetes Association and National Diabetes Data Group.

作者信息

Hickner R C, Brunson M A, McCammon M, Mahar M T, Garry J P, Houmard J A

机构信息

Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858, USA.

出版信息

Diabetologia. 2001 Jan;44(1):26-32. doi: 10.1007/s001250051576.

DOI:10.1007/s001250051576

PMID:11206407

Abstract

AIMS/HYPOTHESIS: In 1997 the American Diabetes Association (ADA) published new categories for diabetes based on fasting plasma glucose that classified diabetes as a plasma glucose of 7.0 mmol/l, or more, rather than one of 7.8 mmol/l or more, as published previously by the National Diabetes Data Group (NDDG) in 1979. We compared the cardiovascular disease risk factors of subjects classified as having Type II (non-insulin-dependent) diabetes mellitus under the NDDG and ADA criteria.

METHODS

We examined a database of approximately 3,700 men (40.4 +/- 11.5 years old) and distributed them into four categories: normal fasting plasma glucose (NFG) of less than 6.1 mmol/l, impaired (IFG) 6.1 to 7.0 mmol/l, ADA diabetic 7.0 to 7.8 mmol/l and NDDG diabetic of 7.8 mmol/l or more.

RESULTS

Fasting glucose was 5.2 +/- 0.5, 6.4 +/- 0.2, 7.3 +/- 0.2 and 11.2 +/- 2.9 mmol/l for the subjects of the NFG, IFG, ADA and NDDG groups, respectively. Estimated treadmill VO2max was 41.4 +/- 8.0, 36.0 +/- 7.8, 32.2 +/- 7.6, 30.6 +/- 7.0 ml x kg(-1) x min(-1) in the NFG, IFG, ADA, and NDDG groups, respectively (NFG and IFG > ADA and NDDG: p < 0.05). The ADA and NDDG groups were also similar for resting and exercise blood pressure and body composition. Triglycerides and total: HDL cholesterol ratios were higher and LDL cholesterol concentration was lower, in the NDDG group than in all other groups (p < 0.05). Total and LDL cholesterol in the ADA and NDDG groups were similar.

CONCLUSION/INTERPRETATION: The similarities in the aerobic capacities, blood pressure and body composition of the ADA and NDDG groups indicate that the decision to lower the cut-off from 7.8 mmol/l to 7.0 mmol/l blood glucose for the clinical classification of diabetes was appropriate. The ADA and NDDG groups, however, might not have identical risks for cardiovascular disease because of differences between total:HDL cholesterol ratios, circulating HDL cholesterol and triglyceride concentrations.

摘要

目的/假设：1997年，美国糖尿病协会（ADA）基于空腹血糖水平发布了糖尿病的新分类，将糖尿病定义为血浆葡萄糖水平达到7.0 mmol/l及以上，而不是像1979年国家糖尿病数据组（NDDG）之前发布的那样为7.8 mmol/l及以上。我们比较了按照NDDG和ADA标准被分类为患有II型（非胰岛素依赖型）糖尿病的受试者的心血管疾病风险因素。

方法

我们研究了一个包含约3700名男性（40.4±11.5岁）的数据库，并将他们分为四类：空腹血糖正常（NFG）低于6.1 mmol/l、空腹血糖受损（IFG）为6.1至7.0 mmol/l、ADA糖尿病患者为7.0至7.8 mmol/l以及NDDG糖尿病患者为7.8 mmol/l及以上。

结果

NFG、IFG、ADA和NDDG组受试者的空腹血糖分别为5.2±0.5、6.4±0.2、7.3±0.2和11.2±2.9 mmol/l。估计的跑步机最大摄氧量在NFG、IFG、ADA和NDDG组中分别为41.4±8.0、36.0±7.8、32.2±7.6、30.6±7.0 ml·kg⁻¹·min⁻¹（NFG和IFG高于ADA和NDDG：p<0.05）。ADA和NDDG组在静息和运动血压以及身体组成方面也相似。NDDG组的甘油三酯以及总胆固醇与高密度脂蛋白胆固醇的比值较高，而低密度脂蛋白胆固醇浓度低于所有其他组（p<0.05）。ADA组和NDDG组的总胆固醇和低密度脂蛋白胆固醇相似。

结论/解读：ADA组和NDDG组在有氧能力、血压和身体组成方面的相似性表明，将糖尿病临床分类的血糖临界值从7.8 mmol/l降低到7.0 mmol/l的决定是合适的。然而，由于总胆固醇与高密度脂蛋白胆固醇的比值、循环中的高密度脂蛋白胆固醇和甘油三酯浓度存在差异，ADA组和NDDG组的心血管疾病风险可能并不相同。