Al-Kuraishy Hayder M, Al-Gareeb Ali I, Waheed Huda J, Al-Maiahy Thabat J
Department of Pharmacology, Toxicology and Medicine, College of Medicine, Almustansiriya University, Baghdad, Iraq.
J Adv Pharm Technol Res. 2018 Jul-Sep;9(3):80-86. doi: 10.4103/japtr.JAPTR_273_18.
Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with abundant adipocytokine changes which may play an important role in the progression of insulin resistance and micro- and macro-vascular complications. Therefore, the objective of this study was to assess the differential effect of metformin alone or in combination with glyburide on apelin serum levels in patients with T2DM. In this case-control study, fifty patients with T2DM in the age range of 45-65 years and twenty-five healthy controls matched for age and body weight were recruited from single endocrinology center, subdivided according to the diabetic pharmacotherapy into: Group I: healthy controls ( = 25), Group II: T2DM patients on metformin ( = 15), Group III: T2DM patients on glyburide ( = 17), and Group IV: T2DM patients on metformin plus glyburide ( = 28). Biochemical and anthropometric variables in relation to apelin serum levels were estimated. Apelin serum levels were low in normal healthy controls compared to T2DM patients ( < 0.01). The differential effect of diabetic pharmacotherapy on apelin serum level was statistically significant ( < 0.01) compared to the controls, but insignificant when compared among used drugs ( > 0.05). Apelin level was high in T2DM compared to the controls; both metformin and glyburide might play a role in this elevation.
2型糖尿病（T2DM）是一种与多种脂肪细胞因子变化相关的代谢紊乱疾病，这些变化可能在胰岛素抵抗以及微血管和大血管并发症的进展中起重要作用。因此，本研究的目的是评估二甲双胍单独使用或与格列本脲联合使用对T2DM患者血清apelin水平的不同影响。在这项病例对照研究中，从单一内分泌中心招募了50名年龄在45 - 65岁之间的T2DM患者和25名年龄及体重匹配的健康对照者，根据糖尿病药物治疗将其分为：第一组：健康对照者（n = 25），第二组：服用二甲双胍的T2DM患者（n = 15），第三组：服用格列本脲的T2DM患者（n = 17），第四组：服用二甲双胍加格列本脲的T2DM患者（n = 28）。评估了与血清apelin水平相关的生化和人体测量学变量。与T2DM患者相比，正常健康对照者的血清apelin水平较低（P < 0.01）。与对照组相比，糖尿病药物治疗对血清apelin水平的不同影响具有统计学意义（P < 0.01），但在所用药物之间比较时无统计学意义（P > 0.05）。与对照组相比，T2DM患者的apelin水平较高；二甲双胍和格列本脲可能都在这种升高过程中起作用。
