Boyle P C, Keesey R E
J Comp Physiol Psychol. 1975 Jan;88(1):218-23. doi: 10.1037/h0076187.
Male rats sustaining lateral hypothalamic (LH) lesions regulated their body weight at a reduced level when maintained for 1 mo. postlesion upon a wet mash diet. Thereafter, for a period of 84 days, half of these animals were offered a high fat dies whereas the remaining animals continued to receive wet mash. A series of palatable drinking solutions were also offered. Body weight remained at reduced levels relative to intact control animals regardless of the diet offered, even under conditions of high fluid intake generated by the palatable drinking solutions. These results contradict the interpretation of Mufson and Wampler that the lower body weight observed in LH-lesioned animals is secondary to lesion-produced "finickiness" and/or dehydration resulting from hypodipsia. Rather, a primary shift in the set point for body weight appears to underlie the reduced levels of weight maintenance in LH-lesioned animals.
遭受下丘脑外侧（LH）损伤的雄性大鼠在损伤后1个月内，以软食喂养时，其体重维持在较低水平。此后，在84天的时间里，这些动物中有一半被给予高脂肪饮食，而其余动物继续接受软食。还提供了一系列可口的饮用溶液。无论提供何种饮食，相对于完整对照动物，体重都保持在较低水平，即使在可口饮用溶液导致高液体摄入量的情况下也是如此。这些结果与Mufson和Wampler的解释相矛盾，他们认为在LH损伤动物中观察到的较低体重是损伤产生的“挑食”和/或因饮水过少导致脱水的继发结果。相反，体重设定点的原发性改变似乎是LH损伤动物体重维持水平降低的基础。
