抗氧化状态对儿童缺铁性贫血中血小板聚集增加的可能影响。
Possible effects of antioxidant status on increased platelet aggregation in childhood iron-deficiency anemia.
作者信息
Tekin D, Yavuzer S, Tekin M, Akar N, Cin S
机构信息
Department of Physiology, Ankara University School of Medicine, Turkey.
出版信息
Pediatr Int. 2001 Feb;43(1):74-7. doi: 10.1046/j.1442-200x.2001.01329.x.
BACKGROUND
Alterations in platelet function and antioxidant status in children with iron-deficiency anemia (IDA) have been reported previously. The present study was performed to better understand possible interactions between these two systems.
METHODS
Erythrocyte superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activity and platelet function were evaluated in 15 children (aged 1 1/2-15 years) with IDA. The antioxidant enzyme activity was determined spectrophotometrically. Platelet aggregation and secretion studies were performed using impedance and bioluminescence methods, respectively. Ten age-matched healthy children were included as a control group.
RESULTS
There were no differences in SOD and CAT activities between patients and controls. However, GSH-Px activity was significantly lower in the iron-deficient children. Platelet aggregation responses to collagen and ADP were also significantly higher in iron-deficient children than in controls.
CONCLUSIONS
Decreased antioxidant defense in IDA may cause increased oxidant stress, which, in turn, may result in a tendency towards platelet aggregation.
背景
先前已有报道缺铁性贫血（IDA）患儿的血小板功能和抗氧化状态存在改变。本研究旨在更好地了解这两个系统之间可能的相互作用。
方法
对15名IDA患儿（年龄1.5 - 15岁）的红细胞超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px）活性以及血小板功能进行评估。采用分光光度法测定抗氧化酶活性。分别使用阻抗法和生物发光法进行血小板聚集和分泌研究。纳入10名年龄匹配的健康儿童作为对照组。
结果
患者与对照组之间SOD和CAT活性无差异。然而，缺铁儿童的GSH-Px活性显著降低。缺铁儿童对胶原和ADP的血小板聚集反应也显著高于对照组。
结论
IDA中抗氧化防御能力下降可能导致氧化应激增加，进而可能导致血小板聚集倾向。
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