缺铁性贫血作为复发性肺栓塞和深静脉血栓形成的罕见危险因素
Iron Deficiency Anemia as a Rare Risk Factor for Recurrent Pulmonary Embolism and Deep Vein Thrombosis.
作者信息
Ezeh Ebubechukwu, Katabi Abdulrahman, Khawaja Imran
机构信息
Internal Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.
Pulmonary Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.
出版信息
Cureus. 2021 Mar 5;13(3):e13721. doi: 10.7759/cureus.13721.
Abstract
Iron deficiency is a well-known cause of anemia. However, it is an under-recognized cause of venous thromboembolism (VTE). Iron deficiency predisposes to VTE mainly by inducing thrombocytosis, which can lead to a hypercoagulable state. Identifying iron deficiency as a possible cause of thromboembolic phenomena has clinical significance since this is a potentially avoidable risk factor. This case report serves as a reminder that iron deficiency is an important risk factor for VTE that should be considered in the evaluation of patients. This is particularly true in patients like ours who have recurrent venous thromboembolic disease.
摘要
缺铁是一种众所周知的贫血病因。然而，它是静脉血栓栓塞症（VTE）的一个未被充分认识的病因。缺铁主要通过诱导血小板增多症导致VTE，而血小板增多症可导致高凝状态。将缺铁视为血栓栓塞现象的一个可能病因具有临床意义，因为这是一个潜在可避免的风险因素。本病例报告提醒人们，缺铁是VTE的一个重要风险因素，在评估患者时应予以考虑。对于像我们的患者这样患有复发性静脉血栓栓塞疾病的人来说尤其如此。
相似文献
1
Iron Deficiency Anemia as a Rare Risk Factor for Recurrent Pulmonary Embolism and Deep Vein Thrombosis.缺铁性贫血作为复发性肺栓塞和深静脉血栓形成的罕见危险因素
Cureus. 2021 Mar 5;13(3):e13721. doi: 10.7759/cureus.13721.
2
The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients.急性近端深静脉血栓形成或肺栓塞患者停用抗凝治疗后复发性静脉血栓栓塞的风险。一项对1626例患者的前瞻性队列研究。
Haematologica. 2007 Feb;92(2):199-205. doi: 10.3324/haematol.10516.
3
Clinical outcomes of patients with pulmonary embolism versus deep vein thrombosis: From the COMMAND VTE Registry.从 COMMAND VTE 登记处看肺栓塞与深静脉血栓患者的临床结局。
Thromb Res. 2019 Dec;184:50-57. doi: 10.1016/j.thromres.2019.10.029. Epub 2019 Nov 1.
4
The risk of recurrent venous thromboembolism in patients with unprovoked symptomatic deep vein thrombosis and asymptomatic pulmonary embolism.无诱因症状性深静脉血栓形成和无症状肺栓塞患者复发性静脉血栓栓塞的风险。
Thromb Haemost. 2006 Mar;95(3):562-6. doi: 10.1160/TH05-10-0677.
5
Persistent Peril: Recurrent Deep Vein Thrombosis and Pulmonary Embolism in a Patient With Protein S Deficiency Despite Optimal Anticoagulation Therapies.持续的风险：尽管采用了最佳抗凝治疗，蛋白S缺乏患者仍反复发生深静脉血栓形成和肺栓塞
Cureus. 2024 May 17;16(5):e60517. doi: 10.7759/cureus.60517. eCollection 2024 May.
6
Current Challenges in Diagnosis of Venous Thromboembolism.静脉血栓栓塞症诊断中的当前挑战
J Clin Med. 2020 Oct 29;9(11):3509. doi: 10.3390/jcm9113509.
7
Isolated calf muscular vein thrombosis is associated with pulmonary embolism and a high incidence of additional ipsilateral and contralateral deep venous thrombosis.孤立性小腿肌静脉血栓形成与肺栓塞以及同侧和对侧附加深静脉血栓形成的高发生率相关。
J Vasc Surg Venous Lymphat Disord. 2013 Jan;1(1):33-8. doi: 10.1016/j.jvsv.2012.04.001. Epub 2012 Dec 8.
8
Reactive Thrombocytosis Related Cerebral Venous Thrombosis: A Rare Complication of Untreated Iron Deficiency Anemia.反应性血小板增多症相关的脑静脉血栓形成：未经治疗的缺铁性贫血的一种罕见并发症。
Cureus. 2021 Oct 26;13(10):e19064. doi: 10.7759/cureus.19064. eCollection 2021 Oct.
9
Aplastic anemia and risk of deep vein thrombosis and pulmonary embolism: A nationwide cohort study.再生障碍性贫血与深静脉血栓和肺栓塞风险：一项全国性队列研究。
Thromb Res. 2017 Jan;149:70-75. doi: 10.1016/j.thromres.2016.11.017. Epub 2016 Nov 21.
10
Subcutaneous unfractionated heparin for the initial treatment of venous thromboembolism.皮下注射普通肝素用于静脉血栓栓塞症的初始治疗。
Cochrane Database Syst Rev. 2017 Feb 14;2(2):CD006771. doi: 10.1002/14651858.CD006771.pub3.
引用本文的文献
1
Predictive Value of Centered Clinical Asymmetric Lower Limb Edema in Diagnosing Deep Vein Thrombosis in Puerperium.产后中心性临床不对称下肢水肿对诊断深静脉血栓形成的预测价值
J Clin Med. 2025 May 9;14(10):3320. doi: 10.3390/jcm14103320.
2
Evaluating Thromboprophylaxis Strategies for High-Risk Pregnancy: A Current Perspective.评估高危妊娠的血栓预防策略：当前视角
Pharmaceuticals (Basel). 2024 Jun 13;17(6):773. doi: 10.3390/ph17060773.
3
Pulmonary Embolism in Patients Admitted With Takotsubo Cardiomyopathy: Prevalence and Associated In-Hospital Adverse Events.应激性心肌病患者并发肺栓塞：患病率及相关院内不良事件
Cureus. 2024 Apr 29;16(4):e59268. doi: 10.7759/cureus.59268. eCollection 2024 Apr.
4
Iron deficiency-induced thrombocytosis presenting with blue toe syndrome.缺铁性血小板增多症伴蓝趾综合征
Clin Case Rep. 2024 Apr 3;12(4):e8596. doi: 10.1002/ccr3.8596. eCollection 2024 Apr.
5
Thyroid Dysfunction in Patients with and Without Venous Thromboembolism: a Case Control Study.有和无静脉血栓栓塞患者的甲状腺功能障碍：一项病例对照研究
Indian J Hematol Blood Transfus. 2023 Oct;39(4):649-654. doi: 10.1007/s12288-023-01643-4. Epub 2023 Apr 17.
6
Efficacy of ferric carboxymaltose in heart failure with iron deficiency: an individual patient data meta-analysis.铁羧基麦芽糖在缺铁性心力衰竭中的疗效：一项个体患者数据荟萃分析。
Eur Heart J. 2023 Dec 21;44(48):5077-5091. doi: 10.1093/eurheartj/ehad586.
7
Serious neurological adverse events following immunization against SARS-CoV-2: a narrative review of the literature.2019冠状病毒病疫苗接种后的严重神经系统不良事件：文献综述
Ther Adv Drug Saf. 2023 May 21;14:20420986231165674. doi: 10.1177/20420986231165674. eCollection 2023.
8
Challenges in Cerebral Venous Thrombosis Management-Case Reports and Short Literature Review.脑静脉血栓形成管理中的挑战——病例报告与简短文献综述
Life (Basel). 2023 Jan 26;13(2):334. doi: 10.3390/life13020334.
9
Trends and Risk Factors for Venous Thromboembolism Among Hospitalized Medical Patients.住院内科患者静脉血栓栓塞症的趋势和风险因素。
JAMA Netw Open. 2022 Nov 1;5(11):e2240373. doi: 10.1001/jamanetworkopen.2022.40373.
本文引用的文献
1
[Iron deficiency, thrombocytosis and thromboembolism].[缺铁、血小板增多症与血栓栓塞]
Wien Med Wochenschr. 2016 Oct;166(13-14):437-446. doi: 10.1007/s10354-016-0514-6. Epub 2016 Sep 28.
2
Iron and thrombosis.铁与血栓形成
Ann Hematol. 2008 Mar;87(3):167-73. doi: 10.1007/s00277-007-0416-1. Epub 2007 Dec 8.
3
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion.缺铁性贫血伴显著血小板增多症并发视网膜中央静脉阻塞
Intern Med. 2005 Oct;44(10):1090-2. doi: 10.2169/internalmedicine.44.1090.
4
Possible effects of antioxidant status on increased platelet aggregation in childhood iron-deficiency anemia.抗氧化状态对儿童缺铁性贫血中血小板聚集增加的可能影响。
Pediatr Int. 2001 Feb;43(1):74-7. doi: 10.1046/j.1442-200x.2001.01329.x.
5
Iron deficiency: a cause of stroke in infants and children.缺铁：婴幼儿及儿童中风的一个病因。
Pediatr Neurol. 1997 Jan;16(1):50-3. doi: 10.1016/s0887-8994(96)00290-1.
6
Serum transferrin saturation, stroke incidence, and mortality in women and men. The NHANES I Epidemiologic Followup Study. National Health and Nutrition Examination Survey.血清转铁蛋白饱和度、女性和男性的中风发病率及死亡率。美国国家健康和营养检查调查（NHANES I）流行病学随访研究。
Am J Epidemiol. 1996 Jul 1;144(1):59-68. doi: 10.1093/oxfordjournals.aje.a008855.
7
Role of iron as a regulator of thrombopoiesis.铁作为血小板生成调节因子的作用。
Am J Med. 1974 Oct;57(4):521-5. doi: 10.1016/0002-9343(74)90001-1.
Zotero 插件