Woodman P G
School of Biological Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
Traffic. 2000 Sep;1(9):695-701. doi: 10.1034/j.1600-0854.2000.010902.x.
Rab5 is a regulatory guanosine triphosphatase that is associated with the sorting endosome and participates in endosomal membrane fusion reactions. Recent experiments have provided insights into Rab5 function by demonstrating direct links between Rab5-interacting proteins and components of the membrane fusion apparatus. In addition, a realisation that Rab5 has additional functions in endosome biogenesis is emerging. These advances may be profoundly important in changing the way that we view the sorting endosome and in developing models that properly reflect the dynamic qualities of the endocytic pathway.
Rab5是一种调节性鸟苷三磷酸酶，与分拣内体相关，并参与内体膜融合反应。最近的实验通过证明Rab5相互作用蛋白与膜融合装置的组分之间的直接联系，为Rab5的功能提供了深入了解。此外，关于Rab5在内体生物发生中具有额外功能的认识正在形成。这些进展对于改变我们看待分拣内体的方式以及开发能够正确反映内吞途径动态特性的模型可能具有极其重要的意义。
