Pakulski C, Drobnik L, Millo B
Department of Anesthesiology and Intensive Care Medicine, Medical University, Szczecin, Poland.
Med Sci Monit. 2000 Mar-Apr;6(2):314-8.
The aim of the study was to find out, if there was a difference in function of the blood/cerebrospinal fluid barrier (BCSFB) in females and males, and if those differences intensify with age.
120 patients of both sexes who underwent subarachnoideal anesthesia were divided into 6 groups, 20 patients each, considering sex and age criteria. Samples of venous blood (5 ml) and cerebrospinal fluid (1 ml) were collected from every patient simultaneously; then albumin permeability indexes (Qalb) were counted. The achieved results were compared using the t-Student test at the significance level of P < or = 0.05.
The mean value of Qalb in patients aged 20-50 was significantly lower than in the group of patients aged 51-70, as well as in the group of patients over 71. The difference between mean Qalb values in patients aged 51-70 and those aged over 71 was also statistically significant. No statistically significant difference between mean Qalb values in females and in males in the corresponding age groups was found. In every age group the value of albumin permeability index was lower in females.
本研究的目的是查明女性和男性的血脑脊髓液屏障（BCSFB）功能是否存在差异，以及这些差异是否会随着年龄的增长而加剧。
将120例接受蛛网膜下腔麻醉的患者按照性别和年龄标准分为6组，每组20例。同时从每位患者采集静脉血样本（5毫升）和脑脊液样本（1毫升）；然后计算白蛋白通透指数（Qalb）。使用t检验对所得结果进行比较，显著性水平为P≤0.05。
20至50岁患者的Qalb平均值显著低于51至70岁患者组以及71岁以上患者组。51至70岁患者与71岁以上患者的平均Qalb值之间的差异也具有统计学意义。在相应年龄组中，未发现女性和男性的平均Qalb值之间存在统计学显著差异。在每个年龄组中，女性的白蛋白通透指数值较低。
1）BCSFB的通透性随年龄增长而增加。2）在相应年龄组中，女性和男性的白蛋白通透指数值之间不存在统计学显著差异。在相应年龄组中，男性和女性的BCSFB功能相同。
