是什么决定了脑脊液中白蛋白和血浆源性免疫球蛋白G的浓度？

What determines the CSF concentrations of albumin and plasma-derived IgG?

作者信息

Seyfert Sepp, Faulstich Andreas, Marx Peter

机构信息

Neurologische Klinik am UKBF, Department of Neurology, University Hospital Benjamin Franklin, Freie Universität Berlin, Berlin D-12200, Germany.

出版信息

J Neurol Sci. 2004 Apr 15;219(1-2):31-3. doi: 10.1016/j.jns.2003.12.002.

DOI:10.1016/j.jns.2003.12.002

PMID:15050434

Abstract

OBJECTIVES

To estimate the mean influence of the main determinants of the cerebrospinal fluid (CSF) concentration of albumin and plasma-derived immunoglobulin G (IgG).

METHODS

Correlations of serum and CSF concentrations of albumin and IgG and assumptions of the mode of action of the determinants (plasma concentration, barrier permeability, and CSF flow) are used to quantify the determinants' influences in a sample of 1700 patients.

RESULTS

We estimated in patients with normal CSF albumin that the serum concentrations of albumin and IgG explained 3.3% and 23% of the variation of the respective CSF concentrations, whereas the barrier permeability accounted for 41.9% and 22.2%, and CSF flow for 54.8%. In patients with pathologic CSF albumin concentration, the serum concentrations were estimated to explain 0.2% and 8.2% of the variation of the respective CSF concentrations, the barrier permeability 19.7% and 11.7%, and CSF flow 80.1%.

CONCLUSIONS

CSF flow had the strongest mean influence, especially at elevated CSF albumin levels. The serum concentrations and barrier permeabilities of albumin and IgG influenced the respective CSF concentrations quite differently, which should be due to the different physicochemical properties of the two molecules. Mean influences from large patient samples, as explored here, can give only an overview. Understanding the determinants in individuals will need further specific measurements, especially of CSF flow.

摘要

目的

评估脑脊液（CSF）中白蛋白和血浆源性免疫球蛋白G（IgG）主要决定因素的平均影响。

方法

利用白蛋白和IgG的血清与脑脊液浓度的相关性以及决定因素（血浆浓度、屏障通透性和脑脊液流动）作用模式的假设，对1700例患者样本中决定因素的影响进行量化。

结果

我们估计，在脑脊液白蛋白正常的患者中，白蛋白和IgG的血清浓度分别解释了相应脑脊液浓度变化的3.3%和23%，而屏障通透性分别占41.9%和22.2%，脑脊液流动占54.8%。在脑脊液白蛋白浓度病理性升高的患者中，血清浓度估计分别解释了相应脑脊液浓度变化的0.2%和8.2%，屏障通透性分别占19.7%和11.7%，脑脊液流动占80.1%。