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慢性乙型和丙型病毒性肝炎患儿的抗氧化防御

Antioxidant defense in children with chronic viral hepatitis B and C.

作者信息

Chrobot A M, Szaflarska-Szczepanik A, Drewa G

机构信息

Department of Pediatrics, Gastroenterology and Allergology, Medical University, ul. Ujejskiego 75, 85-168 Bydgoszcz, Poland.

出版信息

Med Sci Monit. 2000 Jul-Aug;6(4):713-8.

PMID:11208397
Abstract

INTRODUCTION

The aim of the study was estimation of antioxidant defence state in children with chronic viral hepatitis.

MATERIAL AND METHODS

We examined 100 children with chronic viral hepatitis who have serological and molecular markers of HBV or HCV infection. In all patients catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in erythrocytes were assayed.

RESULTS

We observed statistically significant decrease of CAT and SOD activities and increase of GSH-Px activity in children with chronic hepatitis B and C.

CONCLUSIONS

Our data suggest the possibility of insufficiency of antioxidant barrier in children with chronic viral hepatitis.

摘要

引言

本研究的目的是评估慢性病毒性肝炎患儿的抗氧化防御状态。

材料与方法

我们检查了100名患有慢性病毒性肝炎的儿童，他们具有乙肝或丙肝感染的血清学和分子标志物。对所有患者测定了红细胞中的过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）活性。

结果

我们观察到慢性乙型和丙型肝炎患儿的CAT和SOD活性有统计学意义的降低，而GSH-Px活性升高。

结论

我们的数据表明慢性病毒性肝炎患儿存在抗氧化屏障不足的可能性。

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