乳糜泻患儿抗甲状腺抗体发生率的评估。
Estimation of antithyroid antibodies occurrence in children with coeliac disease.
作者信息
Kowalska E, Wasowska-Królikowska K, Toporowska-Kowalska E
机构信息
Department of Gastroenterology and Paediatric Allergology, Institute of Paediatrics, Medical University, ul. Spoma 36/50, 91-738 Łódź, Poland.
出版信息
Med Sci Monit. 2000 Jul-Aug;6(4):719-21.
INTRODUCTION
The coexistence of coeliac disease (CD) and the diseases of autoimmune origin is often discussed in literature. In this study the evaluation of antithyroid antibodies (antimicrosomal-TMA, anti-thyreoglobulin-ATG, thyroid peroxidase antibodies anti-TPO) occurrence against clinical and laboratory determinants of thyroid function is demonstrated in children with coeliac disease.
MATERIAL AND METHODS
The study was conducted on 34 IgA-EmA positive children; control group consisted of 28 children with negative screening tests for coeliac disease.
RESULTS
In both groups, the level of antithyroid antibodies (TMA, ATG, anti-TPO) and determinants of thyroid gland function (TSH, fT3, fT4) were evaluated; USG examination of thyroid gland was also performed. Elevated titres of antithyroid antibodies observed in children with coeliac disease (41.1%) in comparison to control group (3.56%) indicate the need for performing the screening tests for antithyroid antibodies in children with CD.
引言
乳糜泻（CD）与自身免疫性疾病并存的情况在文献中经常被讨论。在本研究中，对患有乳糜泻的儿童针对甲状腺功能的临床和实验室指标的抗甲状腺抗体（抗微粒体-TMA、抗甲状腺球蛋白-ATG、甲状腺过氧化物酶抗体抗-TPO）的出现情况进行了评估。
材料与方法
该研究针对34名IgA-EmA阳性儿童进行；对照组由28名乳糜泻筛查试验阴性的儿童组成。
结果
对两组儿童的抗甲状腺抗体（TMA、ATG、抗-TPO）水平和甲状腺功能指标（TSH、fT3、fT4）进行了评估；还对甲状腺进行了超声检查。与对照组（3.56%）相比，乳糜泻儿童中观察到抗甲状腺抗体滴度升高（41.1%），这表明有必要对患有乳糜泻的儿童进行抗甲状腺抗体筛查试验。
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