Sun Xin, Lu Li, Yang Rong, Li Yanbin, Shan Ling, Wang Yang
Department of Endocrinology and Metabolism, The People's Hospital of China Medical University, Shenyang, P.R. China.
Department of Endocrinology and Metabolism, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, No.33 Wenyi Road, Shenhe District, Shenyang 110013, Liaoning Province, P R China.
PLoS One. 2016 Dec 28;11(12):e0168708. doi: 10.1371/journal.pone.0168708. eCollection 2016.
The prevalence of thyroid disease is likely increased among individuals with celiac disease (CD). In addition, exposure to gluten-free treatment may be associated with a risk of thyroid disease, but this association remains controversial. A systematic review was performed to evaluate the association between thyroid disease and CD. The articles were obtained from the PubMed, Web of Science, Embase, and Chinese WanFang bibliographical databases for the period up to May 2016. The results were analysed in a meta-analysis with odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs). There were 13 articles in this meta-analysis, including 15629 CD cases and 79342 controls. Overall, the prevalence of thyroid disease in patients with CD was significantly increased compared with that in the control groups (OR 3.08, 95% CI 2.67-3.56, P<0.001). Moreover, there was no significant difference in the OR between the gluten-treated and untreated groups (OR 1.08, 95% CI 0.61-1.92, P = 0.786). The results of our meta-analysis support the hypothesis that the prevalence of thyroid disease in patients with CD is increased compared with that in controls, which suggests that CD patients should be screened for thyroid disease. The effect of gluten-free treatment on thyroid disease needs further investigation.
乳糜泻（CD）患者中甲状腺疾病的患病率可能会升高。此外，接受无麸质治疗可能与甲状腺疾病风险相关，但这种关联仍存在争议。进行了一项系统评价以评估甲状腺疾病与CD之间的关联。文章来源于截至2016年5月的PubMed、科学网、Embase和中国万方文献数据库。采用比值比（OR）和相应的95%置信区间（95%CI）进行荟萃分析。该荟萃分析纳入了13篇文章，包括15629例CD病例和79342例对照。总体而言，CD患者中甲状腺疾病的患病率与对照组相比显著升高（OR 3.08，95%CI 2.67 - 3.56，P<0.001）。此外，接受麸质治疗组和未接受治疗组之间的OR无显著差异（OR 1.08，95%CI 0.61 - 1.92，P = 0.786）。我们的荟萃分析结果支持以下假设：与对照组相比，CD患者中甲状腺疾病的患病率升高，这表明应对CD患者进行甲状腺疾病筛查。无麸质治疗对甲状腺疾病的影响需要进一步研究。
