Kopff B, Mucha S, Wolffenbuttel B H, Drzewoski J
Department of Metabolic Diseases and Gastroenterology, Medical University of Łódź, ul. Kopcinskiego 22, 90-153 Łódź, Poland.
Med Sci Monit. 2001 Jan-Feb;7(1):142-7.
Abnormalities of glucose metabolism are a common feature of acromegaly. Overt diabetes mellitus develops in about 10-15% of patients. We present an unusual complication of acromegaly: a 37-year old man with a 2-year history of acromegaly developed diabetic ketoacidosis 3 weeks after transsphenoidal adenomectomy. No specific cause for this sudden metabolic derangement could be demonstrated. Insulin need was very high in the first days after the onset of ketoacidosis, but was considerably reduced after initiation of treatment with octreotide and after successful re-operation.
葡萄糖代谢异常是肢端肥大症的常见特征。约10%-15%的患者会发展为显性糖尿病。我们报告一例肢端肥大症的罕见并发症：一名37岁男性，有2年肢端肥大症病史，在经蝶窦腺瘤切除术后3周发生糖尿病酮症酸中毒。未发现这种突然代谢紊乱的具体原因。酮症酸中毒发作后的头几天胰岛素需求量非常高，但在开始使用奥曲肽治疗和成功再次手术后，胰岛素需求量大幅降低。
