Perz M, Torlińska T
Department of Physiology, Medical University, ul. Swiecickiego 6, 60-781 Poznań, Poland.
Med Sci Monit. 2001 Jan-Feb;7(1):169-77.
The insulin receptor is a complex multifunctional protein located on the cell surface within the fluid mosaic matrix of the plasma membrane. Its ability to bind insulin is determined by structural and spatial specificity, high affinity and reversibility. Insulin action at the cellular level can be considered in three stages. The first stage includes the insulin receptor itself, the insulin substrate (IRS-1) and the molecules that interact with IRS-1. The second stage is that of cascade phosphorylation and dephosphorylation. The third stage concerns the final biological effects of the insulin cascade. The biological specificity of insulin binding and heterogeneity of insulin action in different cells has been well documented. This review intends to summarize the available data of structural and functional characteristics of insulin receptor.
胰岛素受体是一种位于质膜流体镶嵌基质内细胞表面的复杂多功能蛋白质。其结合胰岛素的能力由结构和空间特异性、高亲和力及可逆性决定。胰岛素在细胞水平的作用可分为三个阶段。第一阶段包括胰岛素受体本身、胰岛素底物（IRS - 1）以及与IRS - 1相互作用的分子。第二阶段是级联磷酸化和去磷酸化阶段。第三阶段涉及胰岛素级联反应的最终生物学效应。胰岛素结合的生物学特异性以及不同细胞中胰岛素作用的异质性已有充分记录。本综述旨在总结胰岛素受体结构和功能特性的现有数据。
