Sang Q, Goyal R K
Center for Swallowing and Motility Disorders, West Roxbury Division of Veterans Affairs Boston Healthcare System, West Roxbury, Massachusetts 02132, USA.
Am J Physiol Gastrointest Liver Physiol. 2001 Feb;280(2):G191-200. doi: 10.1152/ajpgi.2001.280.2.G191.
The purpose of the present study was to identify vagal subnuclei that participate in reflex swallowing in response to electrical stimulation of the left superior laryngeal nerve (SLN). SLN stimulation at 10 Hz evoked primary peristalsis, including oropharyngeal and esophageal peristalsis, and LES relaxation. It also induced c-fos expression in interneurons in the interstitial (SolI), intermediate (SolIM), central (SolCe), dorsomedial (SolDM) and commissural (SolC) solitary subnuclei. Neurons in parvicellular reticular nucleus (PCRt) and area postrema (AP) and motoneurons in the semicompact (NAsc), loose (NAl), and compact (NAc) formations of the nucleus ambiguus and both rostral (DMVr) and caudal (DMVc) parts of the dorsal motor nucleus of vagus were also activated. The activated neurons represent all neurons concerned with afferent SLN-mediated reflexes, including the swallowing-related neurons. SLN stimulation at 5 Hz elicited oropharyngeal and LES but not esophageal responses and evoked c-fos expression in neurons in SolI, SolIM, SolDM, PCRt, AP, NAsc, NAl, and DMVc but not in SolCe, NAc, or DMVr. These data are consistent with the role of SolI, SolIM, SolDM, NAsc, NAl, and DMVc circuit in oropharyngeal peristalsis and LES relaxation and SolCe, NAc, DMVc, and DMVr in esophageal peristalsis and LES responses.
本研究的目的是确定参与对左侧喉上神经（SLN）电刺激产生反射性吞咽的迷走神经亚核。以10Hz的频率刺激SLN可诱发原发性蠕动，包括口咽和食管蠕动以及LES松弛。它还诱导了间质（SolI）、中间（SolIM）、中央（SolCe）、背内侧（SolDM）和连合（SolC）孤束亚核中间神经元中的c-fos表达。小细胞网状核（PCRt）和最后区（AP）中的神经元以及疑核半致密（NAsc）、疏松（NAl）和致密（NAc）结构中的运动神经元以及迷走神经背运动核的头端（DMVr）和尾端（DMVc）部分也被激活。这些被激活的神经元代表了所有与SLN传入介导的反射有关的神经元，包括与吞咽相关的神经元。以5Hz的频率刺激SLN可引起口咽和LES反应，但不引起食管反应，并在SolI、SolIM、SolDM、PCRt、AP、NAsc、NAl和DMVc中的神经元中诱发c-fos表达，但在SolCe、NAc或DMVr中未诱发。这些数据与SolI、SolIM、SolDM、NAsc、NAl和DMVc回路在口咽蠕动和LES松弛中的作用以及SolCe、NAc、DMVc和DMVr在食管蠕动和LES反应中的作用一致。
