Cancer epigenetics takes center stage.
作者信息
Feinberg A P
机构信息
Institute of Genetic Medicine, Departments of Medicine, Molecular Biology and Genetics, and Oncology, Johns Hopkins University School of Medicine, 1064 Ross, 720 Rutland Avenue, Baltimore, MD 21205, USA.
出版信息
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):392-4. doi: 10.1073/pnas.98.2.392.
Abstract
摘要
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本文引用的文献
1
Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer.胰岛素样生长因子II基因印记丢失通过双等位基因甲基化发生于结直肠癌中H19相关CTCF结合位点的核心区域。
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):591-6. doi: 10.1073/pnas.98.2.591. Epub 2000 Dec 19.
2
Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive.CTCF与H19基因上游绝缘子的功能关联具有亲本来源特异性且对甲基化敏感。
Curr Biol. 2000 Jul 13;10(14):853-6. doi: 10.1016/s0960-9822(00)00597-2.
3
Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability.散发性结直肠癌伴或不伴微卫星不稳定性的多点印记分析
Int J Oncol. 2000 Aug;17(2):317-22. doi: 10.3892/ijo.17.2.317.
4
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.DNMT1与Rb、E2F1和HDAC1形成复合物，并抑制E2F反应性启动子的转录。
Nat Genet. 2000 Jul;25(3):338-42. doi: 10.1038/77124.
5
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus.CCCTC结合因子（CTCF）介导H19/胰岛素样生长因子2（Igf2）基因座处的甲基化敏感增强子阻断活性。
Nature. 2000 May 25;405(6785):486-9. doi: 10.1038/35013106.
6
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene.一种依赖CTCF的边界的甲基化控制Igf2基因的印记表达。
Nature. 2000 May 25;405(6785):482-5. doi: 10.1038/35013100.
7
Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function.H19印记控制区域中假定的CTCF位点处的母源特异性印记为绝缘子功能提供了证据。
Curr Biol. 2000 May 18;10(10):607-10. doi: 10.1016/s0960-9822(00)00489-9.
8
The 5' flank of mouse H19 in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication.处于异常染色质构象的小鼠H19基因5'侧翼单向阻断增强子与启动子之间的通讯。
Curr Biol. 2000 Apr 20;10(8):449-57. doi: 10.1016/s0960-9822(00)00442-5.
9
CpG island methylator phenotypes in aging and cancer.衰老与癌症中的CpG岛甲基化表型
Semin Cancer Biol. 1999 Oct;9(5):349-57. doi: 10.1006/scbi.1999.0135.
10
Cancer epigenetics comes of age.癌症表观遗传学已然成熟。
Nat Genet. 1999 Feb;21(2):163-7. doi: 10.1038/5947.
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